DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cry and cry1a

DIOPT Version :9

Sequence 1:	NP_732407.1	Gene:	cry / 42305	FlyBaseID:	FBgn0025680	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001070765.2	Gene:	cry1a / 100003956	ZFINID:	ZDB-GENE-010426-2	Length:	619	Species:	Danio rerio

Alignment Length:	522	Identity:	209/522 - (40%)
Similarity:	296/522 - (56%)	Gaps:	49/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VIWFRHGLRLHDNPALLAALADKDQGIALIP-VFIFDGESAGTKNVGYNRMRFLLDSLQDIDDQL 71
            |.|||.||||||||    :|.|...|...:. |:|.|...||:.|||.:|.||||..|:|:|..|
Zfish     6 VHWFRKGLRLHDNP----SLRDSILGAHSVRCVYILDPWFAGSSNVGISRWRFLLQCLEDLDASL 66

  Fly    72 QAATDGRGRLLVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKV 136
            :..   ..||.|..|:|..:|.||.::..::|:..|.|.||...|||.:|:.|..|..::.:.::
Zfish    67 RKL---NSRLFVIRGQPTDVFPRLFKEWNINRLSYEYDSEPFGKERDAAIKKLANEAGVEVIVRI 128

  Fly   137 SHTLWDPQLVIETNGGIPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLFEQ 201
            ||||:|...:||.|||..||||:.|            .|..:|:|   .||...|.. :.::...
Zfish   129 SHTLYDLDKIIELNGGQSPLTYKRF------------QTLISRME---AVETPAETI-TAEVMGP 177

  Fly   202 LPTP---EHFNVYG----DNMGF----LAKINWRGGETQALLLLDERLKVEQHAFERGFYLPNQA 255
            ..||   :|...:|    :.:||    |:...|.||||:||..|:..|  |:.|:...|..|...
Zfish   178 CTTPLSDDHDEKFGVPSLEELGFDTEGLSSAVWPGGETEALTRLERHL--ERKAWVANFERPRMN 240

  Fly   256 LPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREYFYT 320
            ..::..||..:|.:|||||||.|.||:.:.||::.|:..:       :....:.|||:|||:|||
Zfish   241 ANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYRKVKKNS-------SPPLSLYGQLLWREFFYT 298

  Fly   321 MSVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVA 385
            .:.|||.:|:||||.||:.|||.| |...|..|..|:||||.||..|.||..|||:||..|:.||
Zfish   299 AATNNPRFDKMEGNPICVQIPWDK-NPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVA 362

  Fly   386 TFLTRGGLWQSWEHGLQHFLKYLLDADWSVCAGNWMWVS-SSAFERLLDSSLVTCPVALAKRLDP 449
            .|||||.||.|||.|::.|.:.||||||||.||:|||:| ||.|::...   ..|||:..:|.||
Zfish   363 CFLTRGDLWISWEEGMKVFEELLLDADWSVNAGSWMWLSCSSFFQQFFH---CYCPVSFGRRTDP 424

  Fly   450 DGTYIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAVKRNMLAMKSLRN 514
            :|.||::|:|.|...|.:::::||......|:..:|:||||||..::..:.|.:.|:..||.:..
Zfish   425 NGDYIRRYLPVLRGFPAKYIYDPWNAPESVQKAAKCIIGVHYPMPMVHHAEASRLNIERMKQIYQ 489

  Fly   515 SL 516
            .|
Zfish   490 QL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cry	NP_732407.1	PhrB	4..504	CDD:223492	205/508 (40%)
		DNA_photolyase	8..175	CDD:279247	66/167 (40%)
		FAD_binding_7	310..510	CDD:281440	98/200 (49%)
cry1a	NP_001070765.2	PhrB	5..491	CDD:223492	208/520 (40%)
		DNA_photolyase	5..167	CDD:279247	71/182 (39%)
		FAD_binding_7	213..486	CDD:281440	126/285 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2229
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850