DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31475 and sdf4

DIOPT Version :9

Sequence 1:	NP_001262725.1	Gene:	CG31475 / 42303	FlyBaseID:	FBgn0051475	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_998252.1	Gene:	sdf4 / 406360	ZFINID:	ZDB-GENE-040426-2061	Length:	356	Species:	Danio rerio

Alignment Length:	425	Identity:	119/425 - (28%)
Similarity:	193/425 - (45%)	Gaps:	87/425 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FRWLR--CSTLCAILFYMFFIGLILHSTSQKLQQQLKEQGTSSSSSSSSSSSSSSSSSSSSSTQA 73
            |.|.|  .|.|||....:|            :...|..||..::.|:......:|        :.
Zfish     2 FNWRRSQLSCLCASTLAVF------------VMLALNVQGRPANISALKGKQPNS--------KE 46

  Fly    74 DTKMAPNVGHNGAQRWPNTLQELEQQQQKHEQSMRLQPVANNLDSRNENNHRQPHPQSQKVQNAS 138
            |.::.|          |:.|..::.:...|               .|::.|::..  ..|.....
Zfish    47 DNEILP----------PDHLNGVKMEMDGH---------------LNKDFHQEVF--LGKEMEEF 84

  Fly   139 KSPNQPETVILAASNVNEKQILAKAFKRADRSRDGILSIQELGQYINRRIVEHIDEAIMNNAREF 203
            :..::|..        |.|::: :.|.:.|.::|..:|.:|:.::|..:..||..||:..|...|
Zfish    85 EEDSEPRR--------NRKKLI-EIFTKVDINKDRSVSAKEMQRWIMEKTEEHFQEAVRENKLSF 140

  Fly   204 RRVDIGPADGLITWDEYHRFFLREHGMTEADIDE----HDEIRHTALNRRAREDMMRDKARWSEA 264
            |.|| ...|||:|||||...||...|:.|.::.|    ::|::   ::...:|.:...|.||.:|
Zfish   141 RAVD-PDGDGLVTWDEYRVKFLASKGLNEKEVAEKIKNNEELK---VDEETQEVLESLKDRWFQA 201

  Fly   265 AR--TDLFTLTIDEYLSFRHPESSVSNLLELVDDLLRQFDQDGDDQLTLEEFSDLNV-------- 319
            ..  .|.. |..:|:|||.|||.|...|..:|.:::|..|||||.:|||.||..|.:
Zfish   202 DNPPADQL-LNEEEFLSFLHPEHSRGMLRYMVKEIVRDLDQDGDGKLTLAEFISLPMGTVENQQA 265

  Fly   320 -DDDDDLMRKSLISKTLVERREEFKRIIDKNHDGKADRGELLNYVNPKTPRYALQEAATLFSLCD 383
             |.|||.:|         ||::||:.:||.|||......||..|::|.....||.||..:.::.|
Zfish   266 QDIDDDWVR---------ERKKEFEEVIDANHDTIVTMEELEEYMDPMNEHNALNEAKQMIAVAD 321

  Fly   384 ENKDELLTLKEMTDHAEIFLQSKMIDTANSFHTEF 418
            ||::..|.|:|:..::|.|..||::|.|.:.|.||
Zfish   322 ENQNHNLELEEILKYSEYFTGSKLMDYARNVHEEF 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31475	NP_001262725.1	EF-hand_7	160..224	CDD:290234	23/63 (37%)
		EF-hand_7	296..363	CDD:290234	28/75 (37%)
		EFh	301..360	CDD:298682	26/67 (39%)
		EFh	344..398	CDD:298682	19/53 (36%)
sdf4	NP_998252.1	EFh	96..155	CDD:298682	20/60 (33%)
		EF-hand_7	97..156	CDD:290234	21/60 (35%)
		EF-hand_7	194..255	CDD:290234	27/61 (44%)
		EFh	<210..255	CDD:298682	22/44 (50%)
		EF-hand_7	232..301	CDD:290234	29/77 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580659
Domainoid	1	1.000	69	1.000	Domainoid score	I9653
eggNOG	1	0.900	-	-		E1_KOG4251
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32121
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4311
OMA	1	1.010	-	-		QHG49184
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007325
OrthoInspector	1	1.000	-	-		oto38658
orthoMCL	1	0.900	-	-		OOG6_108924
Panther	1	1.100	-	-	LDO	PTHR10827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3736
SonicParanoid	1	1.000	-	-		X5438
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790