DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31475 and Sdf4

DIOPT Version :9

Sequence 1:	NP_001262725.1	Gene:	CG31475 / 42303	FlyBaseID:	FBgn0051475	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_038965121.1	Gene:	Sdf4 / 155173	RGDID:	621521	Length:	405	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	115/433 - (26%)
Similarity:	196/433 - (45%)	Gaps:	85/433 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WLRCST-----LCAILFY-MFFIGLILHSTSQKLQQQLKEQGTSSSSSSSSSSSSSSSSSSSSST 71
            ||...|     ||.:..: ::|:||:|                  ...:::..::.|.|...::.
  Rat    31 WLAAMTSRQRSLCGLAAHGLWFLGLVL------------------LMDATARPANHSFSRERAAN 77

  Fly    72 QADTKMAPNVGHNGAQRWPNTLQELEQQQQK--HEQSMRLQPVANNLDSRNENNHRQPHPQSQKV 134
            :.:.::.|....||.:      .|::....|  |::..    :..::|..:|::  :|....:|
  Rat    78 RDENEIIPPDHLNGVK------LEMDGHLNKDFHQEVF----LGKDMDGFDEDS--EPRRSRRK- 129

  Fly   135 QNASKSPNQPETVILAASNVNEKQILAKAFKRADRSRDGILSIQELGQYINRRIVEHIDEAIMNN 199
                                     |...|.:.|.:.|..:|.:|:..:|..:..||..||:..|
  Rat   130 -------------------------LMVIFSKVDVNTDRRISAKEMQHWIMEKTAEHFQEAVKEN 169

  Fly   200 AREFRRVDIGPADGLITWDEYHRFFLREHGMTEADIDE----HDEIR-------------HTALN 247
            ...||.|| ...||.::||||...||...|..|.:|.:    |:|::             ..:..
  Rat   170 KLHFRAVD-PDGDGHVSWDEYKVKFLASKGHNEREIADAIKNHEELKVDEESWPQTQRLICLSAG 233

  Fly   248 RRAREDMMRDKARWSEAAR--TDLFTLTIDEYLSFRHPESSVSNLLELVDDLLRQFDQDGDDQLT 310
            .:|:|.:...:.||.:|..  .||. ||.||:|||.|||.|...|..:|.:::|..|||||.||:
  Rat   234 SQAQEVLGNLRDRWYQADNPPADLL-LTEDEFLSFLHPEHSRGMLKFMVKEIVRDLDQDGDKQLS 297

  Fly   311 LEEFSDLNVDDDDDLMRKSLISKTLVERREEFKRIIDKNHDGKADRGELLNYVNPKTPRYALQEA 375
            |.||..|.|...::...:.:....:.:|::||:.:||.||||.....||.||::|.....||.||
  Rat   298 LPEFISLPVGTVENQQGQDIDDNWVKDRKKEFEELIDSNHDGIVTMEELENYMDPMNEYNALNEA 362

  Fly   376 ATLFSLCDENKDELLTLKEMTDHAEIFLQSKMIDTANSFHTEF 418
            ..:.::.|||::..|..:|:..::|.|..||::|.|.:.|.||
  Rat   363 KQMIAIADENQNHHLEPEEILKYSEFFTGSKLMDYARNVHEEF 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31475	NP_001262725.1	EF-hand_7	160..224	CDD:290234	22/63 (35%)
		EF-hand_7	296..363	CDD:290234	25/66 (38%)
		EFh	301..360	CDD:298682	22/58 (38%)
		EFh	344..398	CDD:298682	20/53 (38%)
Sdf4	XP_038965121.1	EFh_CREC_cab45	94..390	CDD:320023	93/329 (28%)
		EF-hand motif	94..122	CDD:320023	5/33 (15%)
		EF-hand motif	129..158	CDD:320023	8/54 (15%)
		EF-hand motif	168..197	CDD:320023	13/29 (45%)
		EF-hand motif	242..272	CDD:320023	14/30 (47%)
		EF-hand motif	280..309	CDD:320023	14/28 (50%)
		EF-hand motif	325..354	CDD:320023	14/28 (50%)
		EF-hand motif	361..390	CDD:320023	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340816
Domainoid	1	1.000	43	1.000	Domainoid score	I12069
eggNOG	1	0.900	-	-		E1_KOG4251
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32121
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4252
OMA	1	1.010	-	-		QHG49184
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007325
OrthoInspector	1	1.000	-	-		oto98381
orthoMCL	1	0.900	-	-		OOG6_108924
Panther	1	1.100	-	-	LDO	PTHR10827
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5438
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760