DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5555 and BRAP

DIOPT Version :9

Sequence 1:	NP_001262724.1	Gene:	CG5555 / 42302	FlyBaseID:	FBgn0038686	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_005254001.1	Gene:	BRAP / 8315	HGNCID:	1099	Length:	633	Species:	Homo sapiens

Alignment Length:	542	Identity:	230/542 - (42%)
Similarity:	332/542 - (61%)	Gaps:	47/542 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GLRQSRDITIETYTN--QRWKRELSEPRQQEMNWVAAVQHVNSPSAGSSREITPRSGDDGQAGAS 110
            |.|:..|:.|||..:  ...|..:.|.:..|.          ||:|..|::.: :...:....:.
Human   106 GRREMTDVIIETMKSNPDELKTTVEERKSSEA----------SPTAQRSKDHS-KECINAAPDSP 159

  Fly   111 ASNFPQEIGYFSGNPIVEVTKGLIHLYKKNERKAIKE--APSNQLCLLAVPATLNCHDLLNFIAP 173
            :...|.:|.:|||||.||:..|::||||.|:..::||  ..|..||:|.|||.:..|||:.|:||
Human   160 SKQLPDQISFFSGNPSVEIVHGIMHLYKTNKMTSLKEDVRRSAMLCILTVPAAMTSHDLMKFVAP 224

  Fly   174 CHAEIKHIQIVRDGSPNQFMVLLEFRSNESALEFYKSYNGSTYNSLEPDSLCHAVWV--SEVERS 236
            .:..|:.::|:||.:|||:|||::||:...|..||.:.||..:||:| |.:|..|:|  :||.:|
Human   225 FNEVIEQMKIIRDSTPNQYMVLIKFRAQADADSFYMTCNGRQFNSIE-DDVCQLVYVERAEVLKS 288

  Fly   237 EHGA--PPMGHTELPTCPVCLERMDESVDGVLTILCNHAFHASCLMKWGDSTCPVCRHVQTPGLV 299
            |.||  |.|..||||.|.||||||||||:|:||.||||:||:.||.:|.|:||||||:.|||..|
Human   289 EDGASLPVMDLTELPKCTVCLERMDESVNGILTTLCNHSFHSQCLQRWDDTTCPVCRYCQTPEPV 353

  Fly   300 EDSVCMECEGTDSLWICLICGHVGCGRYQGGHAAAHFRATNHTFAMQLGTSSVWDYAGDNFVHRL 364
            |::.|.||...::|||||||||:|||||...||..||..|.||:||||....||||||||:||||
Human   354 EENKCFECGVQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHRL 418

  Fly   365 FQNKSDGKLVASQTEKDE-REEKIDSMQMEFTYLLTSQLDTQRKYYEERMERLE----QEWQNHK 424
            ..:|:|||:|..:.|.|. :|||||::|:|::|||||||::||.|:|.::.|:|    :|..|.|
Human   419 VASKTDGKIVQYECEGDTCQEEKIDALQLEYSYLLTSQLESQRIYWENKIVRIEKDTAEEINNMK 483

  Fly   425 ATANDAKTEVSELQQLQQNMQKEKVNLERKLAQHTAKLKDVQKQLNEERELSKALQSNQSSWHGK 489
            ....:...:...|:....::.|||.::|||..|...|:..:..:|.||:|::|.|::||.....|
Human   484 TKFKETIEKCDNLEHKLNDLLKEKQSVERKCTQLNTKVAKLTNELKEEQEMNKCLRANQVLLQNK 548

  Fly   490 YKLLEQQYNEFKQTHDAEVTELKEQLRDIMFFLDNQQKL----ANT--EIAGGTV---------- 538
            .|..|:...|.....|.::||::|||||:||:|:.|||:    |.|  ||..|.:
Human   549 LKEEERVLKETCDQKDLQITEIQEQLRDVMFYLETQQKINHLPAETRQEIQEGQINIAMASASSP 613

  Fly   539 --TGIAEKEPDPNTRRRNRRKK 558
              :|.:.|.|.    |:.|.|:
Human   614 ASSGGSGKLPS----RKGRSKR 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5555	NP_001262724.1	RRM_BRAP2	150..234	CDD:241162	38/85 (45%)
		zf-RING_2	249..291	CDD:290367	29/41 (71%)
		zf-UBP	304..363	CDD:280334	37/58 (64%)
		CENP-F_leu_zip	366..517	CDD:287450	57/155 (37%)
		DUF4200	396..517	CDD:290574	43/124 (35%)
BRAP	XP_005254001.1	RRM_BRAP2	201..284	CDD:241162	37/83 (45%)
		RING	304..345	CDD:238093	28/40 (70%)
		zf-UBP	358..420	CDD:280334	40/61 (66%)
		DUF4349	434..599	CDD:305044	62/164 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157317
Domainoid	1	1.000	122	1.000	Domainoid score	I5669
eggNOG	1	0.900	-	-		E1_KOG0804
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4926
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1795
Isobase	1	0.950	-	0	Normalized mean entropy	S1679
OMA	1	1.010	-	-		QHG55462
OrthoDB	1	1.010	-	-		D278227at33208
OrthoFinder	1	1.000	-	-		FOG0005004
OrthoInspector	1	1.000	-	-		oto88534
orthoMCL	1	0.900	-	-		OOG6_102472
Panther	1	1.100	-	-	LDO	PTHR24007
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3020
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720