DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5555 and Brap

DIOPT Version :9

Sequence 1:	NP_001262724.1	Gene:	CG5555 / 42302	FlyBaseID:	FBgn0038686	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001258123.1	Gene:	Brap / 687346	RGDID:	1586551	Length:	591	Species:	Rattus norvegicus

Alignment Length:	604	Identity:	239/604 - (39%)
Similarity:	353/604 - (58%)	Gaps:	68/604 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NISLCVIKIE-TDLDP-SADSEGAVSAEHPTNPRVLKER--------------------ERDRGL 49
            ::||.||::| ....| .||...:.:|...:|..:.|:.                    .:..|.
  Rat     2 SVSLVVIRLELAGHSPVPADFGFSAAAGEMSNEEIKKKTLASAAACLEGKSPGEKAAIIHQHLGR 66

  Fly    50 RQSRDITIETYTNQRWKRELSEPRQQEMNWVAAVQHVNSPSAGSSREITPRSGDDGQA-----GA 109
            |:..|:.|||     .|....|.|...       :...|.:|.||.:   ||.:..::     .:
  Rat    67 REMTDVIIET-----MKASADEFRDTS-------EEKTSSAAPSSAQ---RSREQSESVNTVPDS 116

  Fly   110 SASNFPQEIGYFSGNPIVEVTKGLIHLYKKNERKAIKE--APSNQLCLLAVPATLNCHDLLNFIA 172
            .:...|.:|.:|||||.||:..|::||||.|:..::||  ..|..||:|.||||:..|||:.|:|
  Rat   117 PSKQLPDQISFFSGNPSVEIVHGIMHLYKTNKMTSLKEDVRRSAMLCVLTVPATMTSHDLMKFVA 181

  Fly   173 PCHAEIKHIQIVRDGSPNQFMVLLEFRSNESALEFYKSYNGSTYNSLEPDSLCHAVWV--SEVER 235
            |.:..|:.::|:||.:|||:|||::|.:...|..||.:.||..:||:| |.:|..|:|  :||.:
  Rat   182 PFNDVIEQMKIIRDSTPNQYMVLVKFSAQADADSFYMACNGRQFNSIE-DDVCQLVYVERAEVLK 245

  Fly   236 SEHGA--PPMGHTELPTCPVCLERMDESVDGVLTILCNHAFHASCLMKWGDSTCPVCRHVQTPGL 298
            ||.||  |.|..||||.|.||||||||||:|:||.||||:||:.||.:|.|:||||||:.|||..
  Rat   246 SEDGASLPVMDLTELPKCTVCLERMDESVNGILTTLCNHSFHSQCLQRWDDTTCPVCRYCQTPEP 310

  Fly   299 VEDSVCMECEGTDSLWICLICGHVGCGRYQGGHAAAHFRATNHTFAMQLGTSSVWDYAGDNFVHR 363
            ||::.|.||...::|||||||||:|||||...||..||..|.||:||||....||||||||:|||
  Rat   311 VEENKCFECGVQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHR 375

  Fly   364 LFQNKSDGKLVASQTEKDE-REEKIDSMQMEFTYLLTSQLDTQRKYYEERMERLE----QEWQNH 423
            |..:|:|||:|..:.|.|. :|||||::|:|::|||||||::||.|:|.::.|:|    :|..|.
  Rat   376 LVASKTDGKIVQYECEGDTCQEEKIDALQLEYSYLLTSQLESQRVYWENKIVRIEKDTAEEINNM 440

  Fly   424 KATANDAKTEVSELQQLQQNMQKEKVNLERKLAQHTAKLKDVQKQLNEERELSKALQSNQSSWHG 488
            |:...:...:...|:....::.|||.::|||..|.:.::..:..:|.||:||:|.|::||.....
  Rat   441 KSKFKETIEKCDSLELRLSDLLKEKQSVERKCTQLSTRVAKLSTELQEEQELNKCLRANQLLLQN 505

  Fly   489 KYKLLEQQYNEFKQTHDAEVTELKEQLRDIMFFLDNQQKLAN------TEIAGGTVTGIAEKEPD 547
            |.|..|:...|.....|.::||::|||||:||:|:.||::::      .||..|.:.......|:
  Rat   506 KLKEEERLLKETCAQKDLQITEIQEQLRDVMFYLETQQQISHLPAETRQEIQEGQINIAMASAPN 570

  Fly   548 PNT--------RRRNRRKK 558
            |.:        .|:.|.|:
  Rat   571 PPSSGAGGKLQSRKGRSKR 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5555	NP_001262724.1	RRM_BRAP2	150..234	CDD:241162	38/85 (45%)
		zf-RING_2	249..291	CDD:290367	29/41 (71%)
		zf-UBP	304..363	CDD:280334	37/58 (64%)
		CENP-F_leu_zip	366..517	CDD:287450	57/155 (37%)
		DUF4200	396..517	CDD:290574	43/124 (35%)
Brap	NP_001258123.1	RRM_BRAP2	159..242	CDD:241162	37/83 (45%)
		RING	262..303	CDD:238093	28/40 (70%)
		zf-UBP	316..378	CDD:280334	40/61 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7201
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4926
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2348
OMA	1	1.010	-	-		QHG55462
OrthoDB	1	1.010	-	-		D278227at33208
OrthoFinder	1	1.000	-	-		FOG0005004
OrthoInspector	1	1.000	-	-		oto95671
orthoMCL	1	0.900	-	-		OOG6_102472
Panther	1	1.100	-	-	LDO	PTHR24007
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3020
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980