DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5555 and TRIM39

DIOPT Version :9

Sequence 1:	NP_001262724.1	Gene:	CG5555 / 42302	FlyBaseID:	FBgn0038686	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_067076.2	Gene:	TRIM39 / 56658	HGNCID:	10065	Length:	518	Species:	Homo sapiens

Alignment Length:	360	Identity:	82/360 - (22%)
Similarity:	132/360 - (36%)	Gaps:	93/360 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 TCPVCLERMDESVDGVLTILCNHAFHASCLMKW-----GDSTCPVCRHV----------QTPGLV 299
            :|.||||.:.|.|    .|.|.|.|..:|:.:|     .|..|||||..          |...:|
Human    28 SCSVCLEYLKEPV----IIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMV 88

  Fly   300 E--------------DSVCMECEGTDSLW-------ICLICGHVGCGRYQGGHAAAHFRATNHTF 343
            |              :|:|.:.....||:       :||||                  |.:||.
Human    89 EIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLIC------------------AISHTH 135

  Fly   344 AMQLGTSSVWDYAGDNFVHRLFQ--NKSDGKLVASQTEKDEREEKIDSMQMEFTYLLTSQLDTQR 406
              :..|....|.|...:..:|.:  ...:.||......|...|:|    ..|...|:.|:.....
Human   136 --RAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKK----PGELKRLVESRRQQIL 194

  Fly   407 KYYEERMERLEQEWQNHKATANDAKTEVSELQQLQQN---MQKEKVNLERKLAQHTAK------- 461
            :.:||...||::|.|...:...:.:.::  ||:|::|   :..::.:|....|:...|
Human   195 REFEELHRRLDEEQQVLLSRLEEEEQDI--LQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFE 257

  Fly   462 -LKDVQKQL--NEERELSKALQSNQSSWHGKYKLLEQQYNEFKQTHDAEVTELKEQLRDIMFFLD 523
             ||||:..|  |..|:...:|.:.....|.....|.::.|..::....|||.:..:|........
Human   258 MLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFP 322

  Fly   524 NQ----QKLANTEIAGGTVTGIAEKEPDPNTRRRN 554
            .|    :|:....||..|:        ||.|...|
Human   323 RQYFALRKILKQLIADVTL--------DPETAHPN 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5555	NP_001262724.1	RRM_BRAP2	150..234	CDD:241162
		zf-RING_2	249..291	CDD:290367	17/45 (38%)
		zf-UBP	304..363	CDD:280334	13/65 (20%)
		CENP-F_leu_zip	366..517	CDD:287450	36/165 (22%)
		DUF4200	396..517	CDD:290574	30/133 (23%)
TRIM39	NP_067076.2	RAD18	20..>179	CDD:333230	42/178 (24%)
		RING-HC_TRIM39_C-IV	26..69	CDD:319515	16/44 (36%)
		RING-HC finger (C3HC4-type)	29..69	CDD:319515	16/43 (37%)
		AtpF	175..352	CDD:333342	42/189 (22%)
		Interaction with CDKN1A. /evidence=ECO:0000269\|PubMed:23213251	268..337		12/68 (18%)
		SPRY_PRY_TRIM39	335..513	CDD:293979	7/23 (30%)
		Interaction with CDKN1A. /evidence=ECO:0000269\|PubMed:23213251	389..518
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000