DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5555 and SPAC16E8.13

DIOPT Version :9

Sequence 1:	NP_001262724.1	Gene:	CG5555 / 42302	FlyBaseID:	FBgn0038686	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_594226.1	Gene:	SPAC16E8.13 / 2542333	PomBaseID:	SPAC16E8.13	Length:	547	Species:	Schizosaccharomyces pombe

Alignment Length:	511	Identity:	178/511 - (34%)
Similarity:	272/511 - (53%)	Gaps:	78/511 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 GQAGASASNFPQEIGYFSGNPIVEVTK---GLIHLYKKNERKAIK-EAPSNQLCLLAVPATLNCH 165
            |:....:.:||.     |..|.||.|.   |::|||:....::.: :||...|.:||:|..::..
pombe    42 GEIKLLSMDFPS-----SKVPEVEETSLGHGVVHLYRVFPSESHEFDAPGLILAILAIPLYMSPS 101

  Fly   166 DLLNFIAPCHAE-IKHIQIVRDGSPNQFMVLLEFRSNESALEFYKSYNGSTYNSLEPDSLCHAVW 229
            |:|.|:...|.: |:||::::...||:.|.||:|:...|.:.||..:||..::.::|:: ||.:.
pombe   102 DVLGFLGEKHCKSIQHIRLLKTKDPNRIMALLKFKDQASVIRFYTEFNGKAFSQIDPET-CHVLH 165

  Fly   230 VSEV------ERSEH----------GAPPMGHT-----ELPTCPVCLERMDESVDGVLTILCNHA 273
            :.:|      |.|:.          .:.|...|     |||||.|||||||.|:.|::||:|.|.
pombe   166 IDKVNIKYPMESSDSSSTEQQLVGPSSKPFASTTPALIELPTCVVCLERMDSSITGLITIVCQHT 230

  Fly   274 FHASCLMKWGDSTCPVCRHVQTPGLVE-DSVCMECEGTDSLWICLICGHVGCGRYQGGHAAAHFR 337
            ||..||.|||:|:|||||:.|.....| .|.|..|.....||||||||::|||||...||..|:.
pombe   231 FHCPCLQKWGNSSCPVCRYTQKVQSSEFQSKCTVCCYDKDLWICLICGNIGCGRYHDAHAKQHYV 295

  Fly   338 ATNHTFAMQLGTSSVWDYAGDNFVHRLFQNKSDGKLVASQTE--------KDEREEKI-DSMQME 393
            .|.|.:||:|.|..||||||||:||||.|:::|||||...|:        ....|.|: |.|.:|
pombe   296 DTAHCYAMELETQRVWDYAGDNYVHRLLQSETDGKLVELSTDGKSSGWTGSSATESKLRDKMGLE 360

  Fly   394 FTYLLTSQLDTQRKYYEERMERLEQEWQNHKATAND---AKTEVSELQQLQQNMQKEKVNL-ERK 454
            :|.:|.|||::||.|||..:..:.|:    .:..|:   .||:::..........:.:|:: |.|
pombe   361 YTQILVSQLESQRLYYESHLSNMSQK----LSRVNEELVLKTKIATASSNANTDLRSRVDISESK 421

  Fly   455 LAQHTAKLKDVQKQL-----NEERELSKALQSNQSSWHGKYKLLEQQYNEFKQ----THDAEVTE 510
            |.:...|||.|..||     |.|.|  |::..|...   :.:.||:| |..|.    :...::.:
pombe   422 LKKRDDKLKRVSSQLEHLKHNYEEE--KSMNENLLV---RIQTLEKQ-NTTKSDQIVSMQFQIND 480

  Fly   511 LKEQLRDIMFFLDNQQKL----ANTEIAGGTVTGIAEKEPDPNTRRRN----RRKK 558
            |.|||||:||.:...|::    .:.|:..||:.     .|:.:|.|.|    ::||
pombe   481 LNEQLRDLMFTISASQEIQKMGQSEELQNGTIV-----LPNNSTVRSNSVKSKKKK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5555	NP_001262724.1	RRM_BRAP2	150..234	CDD:241162	26/90 (29%)
		zf-RING_2	249..291	CDD:290367	27/41 (66%)
		zf-UBP	304..363	CDD:280334	33/58 (57%)
		CENP-F_leu_zip	366..517	CDD:287450	50/172 (29%)
		DUF4200	396..517	CDD:290574	37/133 (28%)
SPAC16E8.13	NP_594226.1	RRM_ETP1	88..170	CDD:241161	25/82 (30%)
		RING	207..250	CDD:238093	28/42 (67%)
		zf-UBP	262..324	CDD:280334	36/61 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2211
eggNOG	1	0.900	-	-		E1_KOG0804
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4926
Inparanoid	1	1.050	272	1.000	Inparanoid score	I705
OMA	1	1.010	-	-		QHG55462
OrthoFinder	1	1.000	-	-		FOG0005004
OrthoInspector	1	1.000	-	-		oto100527
orthoMCL	1	0.900	-	-		OOG6_102472
Panther	1	1.100	-	-	LDO	PTHR24007
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R400
SonicParanoid	1	1.000	-	-		X3020
TreeFam	1	0.960	-	-
	14	13.860