DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5555 and Amfr

DIOPT Version :9

Sequence 1:	NP_001262724.1	Gene:	CG5555 / 42302	FlyBaseID:	FBgn0038686	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_035917.2	Gene:	Amfr / 23802	MGIID:	1345634	Length:	639	Species:	Mus musculus

Alignment Length:	287	Identity:	53/287 - (18%)
Similarity:	93/287 - (32%)	Gaps:	71/287 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 CPVCLERMDESVDGVLTILCNHAFHASCLMKW--GDSTCPVCRHVQTPGLVEDSVCMECEGTDSL 313
            |.:|.    :|:.....:.|.|.||.|||..|  .|::||.||  .:..:.:.|...|....::|
Mouse   337 CAICW----DSMQAARKLPCGHLFHNSCLRSWLEQDTSCPTCR--MSLNIADGSRAREDHQGENL 395

  Fly   314 WICLICGHVGCGRYQGGHAAAHFRATNHTFAMQLGTSSVWDYAGDNFVHRLFQNKSDGKLVASQT 378
            ...|:......||.         |...|........|.:..:.....|..:......|...||.:
Mouse   396 DENLVPVAAAEGRP---------RLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQASNS 451

  Fly   379 EKDEREEKIDSMQMEFTYLL----------------------------TSQLDTQRKYYEERMER 415
            :.:....:|..|..:..|.|                            |.:.|:.|......:||
Mouse   452 QLNAMAHQIQEMFPQVPYHLVLQDLQMTRSVEITTDNILEGRIQVPFPTQRSDSLRPALNSPVER 516

  Fly   416 LEQEWQNHKATANDAKTEVSELQQLQQNMQKEKVNLE----------------------RKLAQH 458
            ...:.:..:|:....:..:....:|::.:...:|.||                      |.|.|.
Mouse   517 PSPDLEEGEASVQTERVPLDLSPRLEETLDFSEVELEPIEVEDFEARGSRFSKSADERQRMLVQR 581

  Fly   459 TAKLKDVQKQLNEERELSKALQSNQSS 485
                ||...|...:|.|:|:.:.:.:|
Mouse   582 ----KDDLLQQARKRFLNKSSEDDGAS 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5555	NP_001262724.1	RRM_BRAP2	150..234	CDD:241162
		zf-RING_2	249..291	CDD:290367	14/41 (34%)
		zf-UBP	304..363	CDD:280334	9/58 (16%)
		CENP-F_leu_zip	366..517	CDD:287450	27/170 (16%)
		DUF4200	396..517	CDD:290574	22/140 (16%)
Amfr	NP_035917.2	HRD1	82..>378	CDD:227568	16/46 (35%)
		zf-RING_2	335..375	CDD:290367	14/41 (34%)
		CUE_AMFR	454..494	CDD:270604	4/39 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..531		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620		3/11 (27%)
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250\|UniProtKB:Q9UKV5	618..636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910