Protein Alignment CG5555 and brap-2

DIOPT Version :9

• Sequence 1: NP_001262724.1
• Gene: CG5555 / 42302
• FlyBaseID: FBgn0038686
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_495016.1
• Gene: brap-2 / 173917
• WormBaseID: WBGene00017144
• Length: 590
• Species: Caenorhabditis elegans
• Alignment Length: 597
• Identity: 200/597 - (33%)
• Similarity: 318/597 - (53%)
• Gaps: 92/597 - (15%)

  Fly    20 DPSADSEGAVSAEHP---------TNP-RVLKERERD---------------RGLRQSRDITIET 59
            |..|.||..::.|..         |.| :.||.||.|               :|.|...::.||:
 Worm    27 DSKAGSESPLAGERTRQRLVKKGNTPPKKELKGREEDPPIGVMSSEPSHNYHKGRRTYSEVVIES 91

  Fly    60 YTNQRWKRELSEPRQQEMNWVAAVQHVNSPS--AGSSREITPRSGDDGQAGASASNFPQEIGYFS 122
            ...::.                    |:|.|  ||:|.:...||..:|.        |.::.|:|
 Worm    92 LDGEKL--------------------VDSSSSVAGTSEKSGGRSVSEGP--------PDQVAYYS 128

  Fly   123 GNPIVEVTKGLIHLYKKNERKAIKEAPSNQLCLLAVPATLNCHDLLNFIAPCHAEIKHIQIVRDG 187
            |||:.|.|:|::|.||.|:.|..|.|....||:.||||.:...::::|:......|..|::|||.
 Worm   129 GNPLTEKTEGIMHFYKYNDEKLTKVAQCRMLCMYAVPAQVEVREIISFMCISLPMIVSIKVVRDP 193

  Fly   188 SPNQFMVLLEFRSNESALEFYKSYNGSTYNSLEPDSLCHAVWVSEVE----RSEHGAPPMGHTEL 248
            :|||:|::::|:.:..|:.||:.:|...:|.|| ...|...:|..:|    .....:.....|||
 Worm   194 APNQYMLIIKFKEHNDAVTFYEEFNNCPFNDLE-SYCCTLFFVDRIECTTSNDLFSSDDTSLTEL 257

  Fly   249 PTCPVCLERMDESVDGVLTILCNHAFHASCLMKWGDSTCPVCRHVQTPGLVEDSVCMECEGTDSL 313
            |||.|||||||   |.||.|||||:|||.||.:|.|:||||||:||:|.:|.:..|.:|..::.|
 Worm   258 PTCAVCLERMD---DSVLAILCNHSFHARCLEQWADNTCPVCRYVQSPEVVAEQRCNDCGMSNDL 319

  Fly   314 WICLICGHVGCGRYQGGHAAAHFRATNHTFAMQLGTSSVWDYAGDNFVHRLFQNKSDGKLVASQT 378
            |||||||::|||||...||..|:..|:||:::::|...||||||||:||||.:|.:|||||..|.
 Worm   320 WICLICGNIGCGRYAEQHAQRHWELTSHTYSLKVGGERVWDYAGDNYVHRLIENGADGKLVEYQR 384

  Fly   379 EK----DERE----EKIDSMQMEFTYLLTSQLDTQRKYYEERMERLEQEWQNHKATA-------- 427
            |.    |::.    :|::.:::|:|.||||||:.||||:|.....:||.....:.||
 Worm   385 ESNASFDDKNQKGGDKLEGIKLEYTLLLTSQLEDQRKYFEGLRHDMEQTMSKMEKTAYAQVENLE 449

  Fly   428 ---NDAKTEVSELQ-QLQQNMQKEKVNLERKLAQHTAKLKDVQKQLNEERELSKALQSNQSSWHG 488
               .:..||:..|: .|...:...|| .|::..|...|:..:..:|.:|||:::.|:.:|..|.|
 Worm   450 HQLTERSTELKSLKGDLDDTVTARKV-AEKRATQTNEKVNKLANELKDEREINQMLRKDQQVWKG 513

  Fly   489 KYKLLEQQYNEFKQTHDAEVTELKEQLRDIMFFLDNQQKLANTEIAGGTVT--GIAEKEPD---- 547
            :.:.|.:.....:..::.::.:|:.|:.|::...:.|.|| ..::..|.:|  .|.|.:.:
 Worm   514 QVEKLIESQKTARTEYEKKIEDLQSQVNDLLMHFETQNKL-KEQLDAGKITQEEITESQVELDSS 577

  Fly   548 -PNTRRRNRRKK 558
             .::|:.||:||
 Worm   578 SSSSRKLNRKKK 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5555	NP_001262724.1	RRM_BRAP2	150..234	CDD:241162	26/83 (31%)
		zf-RING_2	249..291	CDD:290367	29/41 (71%)
		zf-UBP	304..363	CDD:280334	31/58 (53%)
		CENP-F_leu_zip	366..517	CDD:287450	47/170 (28%)
		DUF4200	396..517	CDD:290574	35/132 (27%)
brap-2	NP_495016.1	RRM_BRAP2	156..239	CDD:241162	26/83 (31%)
		RING	259..297	CDD:238093	28/40 (70%)
		zf-UBP	310..369	CDD:280334	31/58 (53%)
		TPR_MLP1_2	443..559	CDD:285204	24/117 (21%)
		LRS4	489..>571	CDD:255978	19/82 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165427
Domainoid	1	1.000	89	1.000	Domainoid score	I4976
eggNOG	1	0.900	-	-		E1_KOG0804
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4926
Inparanoid	1	1.050	341	1.000	Inparanoid score	I1391
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55462
OrthoDB	1	1.010	-	-		D278227at33208
OrthoFinder	1	1.000	-	-		FOG0005004
OrthoInspector	1	1.000	-	-		oto19624
orthoMCL	1	0.900	-	-		OOG6_102472
Panther	1	1.100	-	-	LDO	PTHR24007
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R400
SonicParanoid	1	1.000	-	-		X3020
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840