DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5555 and brap

DIOPT Version :9

Sequence 1:	NP_001262724.1	Gene:	CG5555 / 42302	FlyBaseID:	FBgn0038686	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_002937733.1	Gene:	brap / 100488470	XenbaseID:	XB-GENE-491855	Length:	585	Species:	Xenopus tropicalis

Alignment Length:	602	Identity:	238/602 - (39%)
Similarity:	356/602 - (59%)	Gaps:	70/602 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NISLCVIKIE----------------TDLDPSADSEGA--VSAEH-----PTNPRVLKERERDRG 48
            ::||.||::|                |::......|..  |:|.:     |.:...:..:.  .|
Frog     2 SVSLVVIRLELADHSRFPVGFQYCAATEMSDEEVKENTLHVAATYLEGKLPVDKTAILHQH--IG 64

  Fly    49 LRQSRDITIETYTNQRWKRELSEPRQQEMNWVAAVQHVNSPSAGSSREITPRSGDDGQA------ 107
            .|:..|:.|||..        ..|..:    |::.:.::.|.|     :|.::..|.|.
Frog    65 RREMTDMIIETLG--------PSPDVK----VSSTEKMDEPLA-----VTNKASMDEQGICAMAV 112

  Fly   108 -GASASNFPQEIGYFSGNPIVEVTKGLIHLYKKNERKAIKE--APSNQLCLLAVPATLNCHDLLN 169
             .:.:...|::|.:|||||.||:..|::||||.|:..::||  ..|..||:|.||||:..|||:.
Frog   113 PDSPSKQLPEQITFFSGNPSVEIVHGIMHLYKTNKMTSLKEDVRRSAMLCILTVPATMTSHDLMK 177

  Fly   170 FIAPCHAEIKHIQIVRDGSPNQFMVLLEFRSNESALEFYKSYNGSTYNSLEPDSLCHAVWV--SE 232
            |:|..:..|:|::|:||.:|||:|||::|.|...|..||.:.||..:||:|.| :|..|:|  :|
Frog   178 FVASFNEVIEHMKIIRDSTPNQYMVLIKFSSQADADSFYMANNGRQFNSIEED-VCQLVYVERAE 241

  Fly   233 VERSEHGA--PPMGHTELPTCPVCLERMDESVDGVLTILCNHAFHASCLMKWGDSTCPVCRHVQT 295
            |.:||.||  |.|..||||.|.||||||||||:|:||.||||:||:.||.:|.|:||||||:.||
Frog   242 VLKSEDGASLPVMDLTELPKCTVCLERMDESVNGILTTLCNHSFHSQCLQRWEDTTCPVCRYCQT 306

  Fly   296 PGLVEDSVCMECEGTDSLWICLICGHVGCGRYQGGHAAAHFRATNHTFAMQLGTSSVWDYAGDNF 360
            |..||::.|.||...::|||||||||:|||||...||..||..|.||:||||....||||||||:
Frog   307 PEPVEENKCFECGVQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNY 371

  Fly   361 VHRLFQNKSDGKLVASQTEKDE-REEKIDSMQMEFTYLLTSQLDTQRKYYEERMERLE----QEW 420
            ||||..:|:|||:|..:.|.|. ::|||||:|:|::|||||||::||.|:|.::.|||    :|.
Frog   372 VHRLVASKTDGKIVQYECEGDTCQDEKIDSLQLEYSYLLTSQLESQRIYWENKIVRLEKDTAEEI 436

  Fly   421 QNHKATANDAKTEVSELQQLQQNMQKEKVNLERKLAQHTAKLKDVQKQLNEERELSKALQSNQSS 485
            .|.||...:...:...|:....::.|||..:||:.||..:|:..:..:|.||:|::|.|::||:.
Frog   437 NNMKAKFKETIDKCDSLEHRLNDLSKEKQAVERRCAQLNSKVAKLSTELKEEQEMNKCLRANQTM 501

  Fly   486 WHGKYKLLEQQYNEFKQTHDAEVTELKEQLRDIMFFLDNQQKL----ANT--EIAGGTVTGIAEK 544
            ...:.:..|....|..:..|.::.|::|||||:||:|:.|||:    |:|  ||..|.:...:..
Frog   502 LQSRLREEEIMRKETCEQKDVQLLEMQEQLRDVMFYLETQQKINHMPADTRQEIQDGQINIASPS 566

  Fly   545 EPDPN---TRRRNRRKK 558
            .|..:   :.|:.|.|:
Frog   567 SPAASGKLSSRKGRGKR 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5555	NP_001262724.1	RRM_BRAP2	150..234	CDD:241162	39/85 (46%)
		zf-RING_2	249..291	CDD:290367	29/41 (71%)
		zf-UBP	304..363	CDD:280334	37/58 (64%)
		CENP-F_leu_zip	366..517	CDD:287450	56/155 (36%)
		DUF4200	396..517	CDD:290574	42/124 (34%)
brap	XP_002937733.1	RRM_BRAP2	158..241	CDD:241162	38/83 (46%)
		RING-H2_BRAP2	260..303	CDD:319371	30/42 (71%)
		RING-H2 finger (C3H2C3-type)	262..301	CDD:319371	27/38 (71%)
		zf-UBP	315..377	CDD:366940	40/61 (66%)
		SMC_prok_B	<395..564	CDD:274008	62/168 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5608
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4926
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1760
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278227at33208
OrthoFinder	1	1.000	-	-		FOG0005004
OrthoInspector	1	1.000	-	-		oto102409
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3020
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060