DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqz and ZNF705A

DIOPT Version :9

Sequence 1:	NP_524403.1	Gene:	sqz / 42300	FlyBaseID:	FBgn0010768	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_024304748.1	Gene:	ZNF705A / 440077	HGNCID:	32281	Length:	315	Species:	Homo sapiens

Alignment Length:	297	Identity:	84/297 - (28%)
Similarity:	131/297 - (44%)	Gaps:	50/297 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DYLHRSIDQLRSLGHLTTAQLVHDYKPFNISEFRQNVAERLDYSLKNGLVQHQQQMVMEQQPHPD 79
            |.:..:|..|.|||:    |:...|....:.:.::             |.:..::.:.:|  :||
Human    49 DVMLENISHLVSLGY----QISKSYIILQLEQGKE-------------LWREGREFLQDQ--NPD 94

  Fly    80 QQQQQHLHHPQQQQHPPQLK---VSYSAPNS--PPTPHEQQEQKYD-PNRSPPRQQMSSASG--- 135
            ::......| ....||...|   .|.:..||  ...|.|..:...| .:.|...|::.:.||
Human    95 RESALKKKH-MISMHPITRKDASTSMTMENSLILEDPFECNDSGEDCTHSSTITQRLLTHSGKKP 158

  Fly   136 --------SGSNGSSPEEESR---RGDGDQAKPYKCGSCSKSFANSSYLSQHTRIHLGIKPYRCE 189
                    |..|..||:...:   :|     |.|:|..|.|::.|...|.:|...|.|.:||.|.
Human   159 YVSKQCGKSLRNLFSPKPHKQIHTKG-----KSYQCNLCEKAYTNCFRLRRHKMTHTGERPYACH 218

  Fly   190 ICQRKFTQLSHLQQHIRTHTGDKPYKCRHAGCPKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFS 254
            :|.:.|||.|||::|.:||||::||||..  |.|||.|..||:.|.|.|...|.::|:...|.||
Human   219 LCGKAFTQCSHLRRHEKTHTGERPYKCHQ--CGKAFIQSFNLRRHERTHLGKKCYECDKSGKAFS 281

  Fly   255 DEMTLLEHIPKHKDSKHLKTHICNLCGKSYTQETYLQ 291
            .......:...|...   |.|.|.||||:::..:.|:
Human   282 QSSGFRGNKIIHTGE---KPHACLLCGKAFSLSSDLR 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqz	NP_524403.1	C2H2 Zn finger	160..180	CDD:275368	6/19 (32%)
		zf-H2C2_2	172..197	CDD:290200	9/24 (38%)
		zf-C2H2	186..208	CDD:278523	10/21 (48%)
		C2H2 Zn finger	188..208	CDD:275368	9/19 (47%)
		zf-C2H2_8	191..271	CDD:292531	32/79 (41%)
		zf-H2C2_2	200..227	CDD:290200	15/26 (58%)
		C2H2 Zn finger	216..238	CDD:275368	10/21 (48%)
		C2H2 Zn finger	246..266	CDD:275368	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275368	6/15 (40%)
ZNF705A	XP_024304748.1	KRAB	22..81	CDD:214630	8/48 (17%)
		C2H2 Zn finger	133..153	CDD:275368	3/19 (16%)
		COG5048	<136..315	CDD:227381	62/188 (33%)
		C2H2 Zn finger	162..181	CDD:275368	4/18 (22%)
		C2H2 Zn finger	189..209	CDD:275368	6/19 (32%)
		zf-H2C2_2	201..226	CDD:316026	9/24 (38%)
		C2H2 Zn finger	217..237	CDD:275368	9/19 (47%)
		zf-H2C2_2	229..254	CDD:316026	15/26 (58%)
		C2H2 Zn finger	245..265	CDD:275368	10/21 (48%)
		C2H2 Zn finger	273..293	CDD:275368	4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100