DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sqz and wdn

DIOPT Version :9

Sequence 1:NP_524403.1 Gene:sqz / 42300 FlyBaseID:FBgn0010768 Length:535 Species:Drosophila melanogaster
Sequence 2:NP_476900.1 Gene:wdn / 43398 FlyBaseID:FBgn0005642 Length:869 Species:Drosophila melanogaster


Alignment Length:604 Identity:142/604 - (23%)
Similarity:202/604 - (33%) Gaps:220/604 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 PDQQQQQH-LHHPQQQ--QHPP--------QLKVSYSAPNSPPTPHEQQEQKYDPNRS---PPR- 127
            |:|..||| |..||.|  |..|        :|||....|.....|.||...|.:...|   ||. 
  Fly   168 PEQLHQQHQLQMPQSQLLQRKPKLPAATAVRLKVFKEEPPEEKHPPEQVVTKVEVCESELLPPSF 232

  Fly   128 ---QQMSSASGSGS----------------------------NG---SSPEE------------- 145
               ||..||.....                            ||   .:|:|             
  Fly   233 TIFQQAKSAESVADAASMPPPAASETKPLEVDPAPLHKCLDCNGLLLETPDEVAKHEAAAHRLRL 297

  Fly   146 ---------------------ESRRGDG---------------------------DQAKPYKCGS 162
                                 ::.|.:|                           ...|.|:|..
  Fly   298 TYRCSECQREFELLAGLKKHLKTHRTEGRKDTWKKCPDCGKCLKLGSMWMHRKIHSDNKKYQCDI 362

  Fly   163 CSKSFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHAG------- 220
            |.:.|.....|:.|.|||...|||.|..||::|.:.||||:|.:.|...:.|:|...|       
  Fly   363 CGQKFVQKINLTHHARIHSSEKPYECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKTER 427

  Fly   221 -------------------CPKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEMTLLEHIPK- 265
                               |.|:|...|.|:.||..|...:|||||.|.:.|::....|:|..: 
  Fly   428 CLKVHNLVHLEQRPFACTVCDKSFISNSKLKQHSNIHTGMRPFKCNYCPRDFTNFPNWLKHTRRR 492

  Fly   266 ----HKDSKHLKTHICNLCGKSYTQETYLQKHLQKHAEKAEKQQHRHTAQVAAHQQHVPASGIGL 326
                ||..:||: :|.:.|.|..|            ..||:|      |..||......:|.:..
  Fly   493 HKVDHKTGEHLE-NIPSYCSKKST------------TNKAQK------AAAAAAAAAAASSAVNP 538

  Fly   327 NLQRQAMNDVNAAYWAKMGADSAAASLAEAIQQQLPQAG-------GQPYGNFASLQQQH----- 379
            | :..|.:::.|.  |.:.:.:|.|...:|.:::.||..       ..|.|  .:|||.|     
  Fly   539 N-ELSASSELKAK--ANLTSTAAPAPAKQARKKKQPQQATLAALGITLPAG--TALQQVHPVPLA 598

  Fly   380 QQQQQELLHHQRLADTPGHSHSPHEEAAGEDLVLRQSTPQHHLQQQQQQQQQQQAQQQQQAQHQP 444
            ||.||||    .....|....:|.:..|..:  .:|..|    :|.||:.|..|..|.||:..:|
  Fly   599 QQHQQEL----TTVLVPLAPPAPKQTKAKRE--RKQLAP----KQLQQKPQLLQQGQPQQSSLEP 653

  Fly   445 SPGPGNSAFTPLSATVAPPPHLQQHRGPPGSAAAYLYQQ-----------------------NAA 486
            .|........|:.   ...|.|..|.....||...:.:|                       ||.
  Fly   654 IPAVPQIKKEPVQ---TQGPFLDLHGLSLTSAEELIMEQALEMEECGLYDAPNANTEMGTSDNAI 715

  Fly   487 AAAAAFPTQLISLH-QIRN 504
            :.:||      :|| ||:|
  Fly   716 SDSAA------ALHFQIKN 728

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sqzNP_524403.1 C2H2 Zn finger 160..180 CDD:275368 6/19 (32%)
zf-H2C2_2 172..197 CDD:290200 12/24 (50%)
zf-C2H2 186..208 CDD:278523 10/21 (48%)
C2H2 Zn finger 188..208 CDD:275368 9/19 (47%)
zf-C2H2_8 191..271 CDD:292531 31/110 (28%)
zf-H2C2_2 200..227 CDD:290200 11/52 (21%)
C2H2 Zn finger 216..238 CDD:275368 9/47 (19%)
C2H2 Zn finger 246..266 CDD:275368 6/24 (25%)
C2H2 Zn finger 277..297 CDD:275368 3/19 (16%)
wdnNP_476900.1 C2H2 Zn finger 301..321 CDD:275368 0/19 (0%)
RPB9 333..425 CDD:224510 26/91 (29%)
C2H2 Zn finger 333..352 CDD:275368 0/18 (0%)
zf-H2C2_2 344..369 CDD:290200 5/24 (21%)
zf-C2H2 358..380 CDD:278523 7/21 (33%)
C2H2 Zn finger 360..380 CDD:275368 6/19 (32%)
zf-H2C2_2 372..395 CDD:290200 11/22 (50%)
zf-C2H2 386..408 CDD:278523 10/21 (48%)
C2H2 Zn finger 388..436 CDD:275368 13/47 (28%)
zf-H2C2_2 400..425 CDD:290200 8/24 (33%)
C2H2 Zn finger 416..433 CDD:275368 2/16 (13%)
zf-H2C2_2 429..453 CDD:290200 3/23 (13%)
C2H2 Zn finger 444..464 CDD:275368 7/19 (37%)
zf-H2C2_2 457..481 CDD:290200 11/23 (48%)
C2H2 Zn finger 472..493 CDD:275368 6/20 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45457125
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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