DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sqz and ZNF850

DIOPT Version :9

Sequence 1:	NP_524403.1	Gene:	sqz / 42300	FlyBaseID:	FBgn0010768	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	473	Identity:	115/473 - (24%)
Similarity:	181/473 - (38%)	Gaps:	137/473 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QLVH-DYKPFNISEFRQNVAERLDYSLKNGLVQHQQQMVMEQQPHPDQQ------------QQQH 85
            |.:| ..||::..|..::      ::.::||:.||.....| :|:..::            |.|.
Human   524 QRIHTGEKPYHCKECGKS------FTFRSGLIGHQAVHTGE-KPYDCKECGKSFTSRSALIQHQR 581

  Fly    86 LHHPQQQQHPPQLKVSYSAPNSPPTPHEQ---QEQKYDPN----------RSPPRQQMSSASGSG 137
            :|..::..|..:...|::. .|....|:|   .|:.||..          |....||:.:..
Human   582 IHTGEKPYHCKECGKSFTV-GSTLLQHQQIHTGEKPYDCKECGKAFRLRLRLTQHQQIHTGE--- 642

  Fly   138 SNGSSPEEESRRGDGDQAKPYKCGSCSKSFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQ 202
                              |||:|..|.|:|.:.|.|:||.|||.|.|||.|..|.:.|.|.::|.
Human   643 ------------------KPYQCQECGKAFVSVSGLTQHHRIHTGEKPYECPDCGKAFRQRTYLN 689

  Fly   203 QHIRTHTGDKPYKCRHAG--------------------------CPKAFSQLSNLQSHSRCHQTD 241
            ||.|.|||:|||:|:..|                          |.|:|:..|.|..|.:.|..:
Human   690 QHRRIHTGEKPYECKECGKSFTFCSGLIQHQQNHTDEKPYDGKECGKSFTSHSTLIQHQQIHTGE 754

  Fly   242 KPFKCNSCYKCFSDEMTLLEHIPKHKDSKHLKTHICNLCGKSYTQETYLQKHLQKHAEKAEKQQH 306
            ||:.|..|.|.|:...||::|...|...   |.:.|..||||:|..:.|.:|...|.  .||..|
Human   755 KPYDCKECGKSFTSHSTLIQHQQIHTGE---KLYDCKECGKSFTSHSTLIQHQPLHT--GEKPYH 814

  Fly   307 -----RHTAQVAAHQQHVPASGIGLNLQRQAMNDVNAAYWAKMGADSAAASLAEAIQQQLPQAGG 366
                 :.....:|..||.|   :....:|.:..:...::          .|.:..|:.|....|.
Human   815 CKECGKSFTLRSALIQHRP---VHTGEKRYSCKECGKSF----------TSRSTLIEHQRIHTGE 866

  Fly   367 QPY-----GN---FASLQQQHQ------------------QQQQELLHHQRL--ADTPGHSHSPH 403
            :||     |.   |.|...||:                  :::.:|..|||:  .:.|...|.
Human   867 KPYHCKECGKSFAFRSAIIQHRRIHTGEKPYDCKECGKAFRRRSKLTQHQRIHTGEKPYRCHE-- 929

  Fly   404 EEAAGEDLVLRQSTPQHH 421
               .|:..|......:||
Human   930 ---CGKAFVRFSGLTKHH 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqz	NP_524403.1	C2H2 Zn finger	160..180	CDD:275368	9/19 (47%)
		zf-H2C2_2	172..197	CDD:290200	13/24 (54%)
		zf-C2H2	186..208	CDD:278523	9/21 (43%)
		C2H2 Zn finger	188..208	CDD:275368	8/19 (42%)
		zf-C2H2_8	191..271	CDD:292531	32/105 (30%)
		zf-H2C2_2	200..227	CDD:290200	15/52 (29%)
		C2H2 Zn finger	216..238	CDD:275368	8/47 (17%)
		C2H2 Zn finger	246..266	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..244	CDD:275368
		COG5048	243..659	CDD:227381	32/163 (20%)
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	296..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-H2C2_2	324..348	CDD:290200
		C2H2 Zn finger	339..359	CDD:275368
		zf-H2C2_2	351..375	CDD:290200
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		C2H2 Zn finger	423..443	CDD:275368
		zf-H2C2_2	436..460	CDD:290200
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..487	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
		zf-H2C2_2	493..516	CDD:290200
		C2H2 Zn finger	507..527	CDD:275368	1/2 (50%)
		zf-H2C2_2	519..543	CDD:290200	5/24 (21%)
		COG5048	531..947	CDD:227381	113/466 (24%)
		C2H2 Zn finger	535..555	CDD:275368	5/25 (20%)
		C2H2 Zn finger	563..583	CDD:275368	2/19 (11%)
		zf-H2C2_2	575..599	CDD:290200	5/23 (22%)
		C2H2 Zn finger	591..611	CDD:275368	4/20 (20%)
		C2H2 Zn finger	619..639	CDD:275368	3/19 (16%)
		zf-H2C2_2	632..656	CDD:290200	9/44 (20%)
		C2H2 Zn finger	647..667	CDD:275368	9/19 (47%)
		zf-H2C2_2	660..684	CDD:290200	13/23 (57%)
		C2H2 Zn finger	675..695	CDD:275368	8/19 (42%)
		zf-H2C2_2	687..711	CDD:290200	12/23 (52%)
		C2H2 Zn finger	703..723	CDD:275368	2/19 (11%)
		C2H2 Zn finger	732..751	CDD:275368	6/18 (33%)
		C2H2 Zn finger	759..779	CDD:275368	7/19 (37%)
		C2H2 Zn finger	787..807	CDD:275368	8/19 (42%)
		C2H2 Zn finger	815..835	CDD:275368	4/22 (18%)
		C2H2 Zn finger	843..863	CDD:275368	3/29 (10%)
		zf-H2C2_2	856..879	CDD:290200	6/22 (27%)
		C2H2 Zn finger	871..891	CDD:275368	5/19 (26%)
		C2H2 Zn finger	899..919	CDD:275368	4/19 (21%)
		zf-H2C2_2	912..936	CDD:290200	7/28 (25%)
		C2H2 Zn finger	927..947	CDD:275368	5/23 (22%)
		C2H2 Zn finger	955..975	CDD:275368
		zf-H2C2_2	967..992	CDD:290200
		C2H2 Zn finger	983..1003	CDD:275368
		zf-H2C2_2	995..1020	CDD:290200
		C2H2 Zn finger	1011..1031	CDD:275368
		zf-H2C2_2	1024..1046	CDD:290200
		C2H2 Zn finger	1039..1059	CDD:275368
		zf-H2C2_2	1052..1076	CDD:290200
		C2H2 Zn finger	1067..1087	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910