DRSC/TRiP Functional Genomics Resources

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Protein Alignment sqz and ZNF454

DIOPT Version :9

Sequence 1:NP_524403.1 Gene:sqz / 42300 FlyBaseID:FBgn0010768 Length:535 Species:Drosophila melanogaster
Sequence 2:NP_001171560.1 Gene:ZNF454 / 285676 HGNCID:21200 Length:522 Species:Homo sapiens


Alignment Length:363 Identity:96/363 - (26%)
Similarity:156/363 - (42%) Gaps:61/363 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 YSLKNGLVQHQQQMVMEQQPHPDQQQQQHLHHPQQQQHPPQLKVSYSAPNSPPTPHEQQEQKYDP 121
            :|..:.|.:|       |:.|.::...|.:|..:::....:...::.     .:.|....|:...
Human   187 FSKSSTLNKH-------QKIHNEKNANQKIHIKEKRYECRECGKAFH-----QSTHLIHHQRIHT 239

  Fly   122 NRSPPRQQMSSASGSGSNGSSPEEESRRGDGDQAKPYKCGSCSKSFANSSYLSQHTRIHLGIKPY 186
            ...|...:....:.|.|:..:..::...|:    ||::|..|.|:|..:.:|:.|.|||.|.||:
Human   240 GEKPYECKECGKAFSVSSSLTYHQKIHTGE----KPFECNLCGKAFIRNIHLAHHHRIHTGEKPF 300

  Fly   187 RCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHAGCPKAFSQLSNLQSHSRCHQTDKPFKCNSCYK 251
            :|.||::.|...:||.:|...|:|:|||||..  |.|||:|.::...|.|.|..:|||:||.|.|
Human   301 KCNICEKAFVCRAHLTKHQNIHSGEKPYKCNE--CGKAFNQSTSFLQHQRIHTGEKPFECNECGK 363

  Fly   252 CFSDEMTLLEHIPKHKDSKHLKTHICNLCGKSYTQETYLQKHLQKH----------AEKAEKQQH 306
            .|....:|.||...|...|..|   ||.|||::...:...:|.:.|          .|||.:.| 
Human   364 AFRVNSSLTEHQRIHTGEKPYK---CNECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKAFRDQ- 424

  Fly   307 RHTAQVAAHQQ-HVPASGIGLNLQRQAMNDVNA------------AYWAKMGADSAAASLAEAIQ 358
               :.:|.||: |........|:..:|.:|.:|            .|..|: .:.|........|
Human   425 ---SALAQHQRIHTGEKPYTCNICEKAFSDHSALTQHKRIHTREKPYKCKI-CEKAFIRSTHLTQ 485

  Fly   359 QQLPQAGGQPY-----GNFASLQQQHQQQQQELLHHQR 391
            .|....|.:||     |...:       |...|:.|||
Human   486 HQRIHTGEKPYKCNKCGKAFN-------QTANLIQHQR 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sqzNP_524403.1 C2H2 Zn finger 160..180 CDD:275368 7/19 (37%)
zf-H2C2_2 172..197 CDD:290200 12/24 (50%)
zf-C2H2 186..208 CDD:278523 7/21 (33%)
C2H2 Zn finger 188..208 CDD:275368 7/19 (37%)
zf-C2H2_8 191..271 CDD:292531 32/79 (41%)
zf-H2C2_2 200..227 CDD:290200 14/26 (54%)
C2H2 Zn finger 216..238 CDD:275368 8/21 (38%)
C2H2 Zn finger 246..266 CDD:275368 8/19 (42%)
C2H2 Zn finger 277..297 CDD:275368 6/19 (32%)
ZNF454NP_001171560.1 KRAB 14..73 CDD:214630
KRAB 14..53 CDD:279668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..170
zf-C2H2 178..200 CDD:278523 4/19 (21%)
C2H2 Zn finger 180..200 CDD:275368 4/19 (21%)
COG5048 186..522 CDD:227381 96/363 (26%)
C2H2 Zn finger 218..238 CDD:275368 2/24 (8%)
zf-H2C2_2 230..254 CDD:290200 3/23 (13%)
C2H2 Zn finger 246..266 CDD:275368 2/19 (11%)
zf-H2C2_2 258..283 CDD:290200 7/28 (25%)
C2H2 Zn finger 274..294 CDD:275368 7/19 (37%)
zf-H2C2_2 286..311 CDD:290200 12/24 (50%)
C2H2 Zn finger 302..322 CDD:275368 7/19 (37%)
zf-H2C2_2 314..339 CDD:290200 14/26 (54%)
C2H2 Zn finger 330..350 CDD:275368 8/21 (38%)
zf-H2C2_2 342..365 CDD:290200 10/22 (45%)
C2H2 Zn finger 358..378 CDD:275368 8/19 (42%)
zf-H2C2_2 370..393 CDD:290200 11/25 (44%)
C2H2 Zn finger 386..406 CDD:275368 6/19 (32%)
zf-H2C2_2 398..421 CDD:290200 4/22 (18%)
C2H2 Zn finger 414..434 CDD:275368 7/23 (30%)
zf-H2C2_2 426..450 CDD:290200 6/23 (26%)
C2H2 Zn finger 442..462 CDD:275368 4/19 (21%)
zf-H2C2_2 454..479 CDD:290200 4/25 (16%)
C2H2 Zn finger 470..490 CDD:275368 4/20 (20%)
zf-H2C2_2 482..507 CDD:290200 6/31 (19%)
C2H2 Zn finger 498..518 CDD:275368 6/26 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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