DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqz and ZNF384

DIOPT Version :9

Sequence 1:	NP_524403.1	Gene:	sqz / 42300	FlyBaseID:	FBgn0010768	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001372672.1	Gene:	ZNF384 / 171017	HGNCID:	11955	Length:	608	Species:	Homo sapiens

Alignment Length:	309	Identity:	128/309 - (41%)
Similarity:	157/309 - (50%)	Gaps:	81/309 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 KPYKCGSCSKSFANSSYLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHAG 220
            ||:||..|||:|||:|||:||.|||.|.|||.|..||:.|.||||||||.|.||||:||||.|.|
Human   346 KPHKCPHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQLSHLQQHTRIHTGDRPYKCAHPG 410

  Fly   221 CPKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFSDEMTLLEHIPKHKDSKHLKTHICNLCGKSYT 285
            |.|||:||||||||.|.|..||||||::|::.::|..:|..|:..| ..||.|.:.|.:|.::||
Human   411 CEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEVHLSTH-TVKHAKVYTCTICSRAYT 474

  Fly   286 QETYLQKHLQKHAEKAEKQQHRHTAQVAAHQQHVPASGIGLNLQRQAMNDVNAAYWAKMGADSAA 350
            .||||.||::||                    :.|      :||:|    |.||        :||
Human   475 SETYLMKHMRKH--------------------NPP------DLQQQ----VQAA--------AAA 501

  Fly   351 ASLAEAIQQQLPQAGGQPYGNFASLQQQHQQQQQELLHHQRLADTPGHSHSPHEEAAGEDLVLRQ 415
            |::|:|..|...||..|     |..|.|.|..|..
Human   502 AAVAQAQAQAQAQAQAQ-----AQAQAQAQASQAS------------------------------ 531

  Fly   416 STPQHHLQQQQQQQQQQQAQQQQQAQHQPSPGPGNSAFTPLSATVAPPP 464
                   |||||||||||.||||...|..|||..........:...|||
Human   532 -------QQQQQQQQQQQQQQQQPPPHFQSPGAAPQGGGGGDSNPNPPP 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqz	NP_524403.1	C2H2 Zn finger	160..180	CDD:275368	13/19 (68%)
		zf-H2C2_2	172..197	CDD:290200	15/24 (63%)
		zf-C2H2	186..208	CDD:278523	14/21 (67%)
		C2H2 Zn finger	188..208	CDD:275368	13/19 (68%)
		zf-C2H2_8	191..271	CDD:292531	47/79 (59%)
		zf-H2C2_2	200..227	CDD:290200	20/26 (77%)
		C2H2 Zn finger	216..238	CDD:275368	16/21 (76%)
		C2H2 Zn finger	246..266	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	10/19 (53%)
ZNF384	NP_001372672.1	C2H2 Zn finger	261..281	CDD:275368
		COG5048	<284..486	CDD:227381	83/140 (59%)
		C2H2 Zn finger	289..309	CDD:275368
		C2H2 Zn finger	317..337	CDD:275368
		C2H2 Zn finger	350..370	CDD:275368	13/19 (68%)
		C2H2 Zn finger	378..398	CDD:275368	13/19 (68%)
		C2H2 Zn finger	406..428	CDD:275368	16/21 (76%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		C2H2 Zn finger	466..486	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7661
SonicParanoid	1	1.000	-	-		X6293
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940