Protein Alignment sqz and ZNF846

DIOPT Version :10

• Sequence 1: NP_524403.1
• Gene: sqz / 42300
• FlyBaseID: FBgn0010768
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_001071092.1
• Gene: ZNF846 / 162993
• HGNCID: 27260
• Length: 533
• Species: Homo sapiens
• Alignment Length: 315
• Identity: 99/315 - (31%)
• Similarity: 153/315 - (48%)
• Gaps: 34/315 - (10%)

  Fly     1 MAELPTAPNGVPSGDYLHRSID-QLRSLGHLTTAQLVHDYKPFNISEFRQNVAERLDYSLKNGLV 64
            |.||.|...||      .:.:| ||::.|......:..:..|..:...|.|.||:|..|..:|.|
Human    64 MEELRTGVTGV------LQELDLQLKTKGSPLLQDISAERSPNGVQLERSNTAEKLYDSNHSGKV 122

  Fly    65 QHQQQMVME-------QQPHPDQQQQQHLHHPQQQQHPPQL-KVSYSAPNSPP-TPHEQQEQKYD 120
            .::...:|.       ::...|.|..:.|    ::..|... |.|::....|. ..||:...::.
Human   123 FNEHPFLMTHMITHIGEKTSEDNQSGKAL----RKNFPHSFYKKSHAEGKMPKCVKHEKAFNQFP 183

  Fly   121 ----PNRSPPRQQMSSASG---SGSNGSSPEEESRRGDGDQAKPYKCGSCSKSFANSSYLSQHTR 178
                .|::..::::.....   :..|.||.:...|..:||  |.|.|..|.|:|:|||:|..|.|
Human   184 NLTRQNKTHTQEKLCECKDCWRTFLNQSSLKLHIRSHNGD--KHYVCKECGKAFSNSSHLIGHGR 246

  Fly   179 IHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHAGCPKAFSQLSNLQSHSRCHQTDKP 243
            ||.|.|||.|:.|.:.|||.:.|:.|||||:|:|||||:.  |.|||:..|.|..|:|.|...||
Human   247 IHSGEKPYVCKECGKAFTQSTGLKLHIRTHSGEKPYKCKE--CGKAFTHSSYLTDHTRIHSGKKP 309

  Fly   244 FKCNSCYKCFSDEMTLLEHIPKHKDSKHLKTHICNLCGKSYTQETYLQKHLQKHA 298
            :.|..|.|.|:....|:.|:..|...   |.:.|..|||::...:||.||::.|:
Human   310 YVCMECGKAFTRSTGLILHMRIHTGE---KPYECKECGKAFIHSSYLTKHVRIHS 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sqz	NP_524403.1	C2H2 Zn finger	160..180	CDD:275368	10/19 (53%)
		COG5048	184..>288	CDD:227381	43/103 (42%)
		C2H2 Zn finger	188..208	CDD:275368	9/19 (47%)
		C2H2 Zn finger	216..238	CDD:275368	9/21 (43%)
		C2H2 Zn finger	246..266	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
ZNF846	NP_001071092.1	KRAB	8..67	CDD:214630	1/2 (50%)
		COG5048	106..496	CDD:227381	88/267 (33%)
		C2H2 Zn finger	120..136	CDD:275368	3/15 (20%)
		C2H2 Zn finger	200..220	CDD:275368	4/19 (21%)
		C2H2 Zn finger	228..248	CDD:275368	10/19 (53%)
		C2H2 Zn finger	256..276	CDD:275368	9/19 (47%)
		C2H2 Zn finger	284..304	CDD:275368	9/21 (43%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	368..388	CDD:275368
		C2H2 Zn finger	396..416	CDD:275368
		C2H2 Zn finger	424..444	CDD:275368
		C2H2 Zn finger	452..472	CDD:275368
		C2H2 Zn finger	480..500	CDD:275368
		zf-H2C2_2	492..517	CDD:463886
		C2H2 Zn finger	508..527	CDD:275368