DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11779 and TIM44

DIOPT Version :9

Sequence 1:	NP_650786.2	Gene:	CG11779 / 42298	FlyBaseID:	FBgn0038683	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_012242.1	Gene:	TIM44 / 854790	SGDID:	S000001284	Length:	431	Species:	Saccharomyces cerevisiae

Alignment Length:	418	Identity:	126/418 - (30%)
Similarity:	205/418 - (49%)	Gaps:	76/418 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 FFDNMKAEMDKNKEIKDNIRKFREEAQKLEESDALKSARQKFNIVESEAQKSSSMLKEQLGAIKE 140
            |.|..|.|.:|::|:::||:..::.:.||.||:|.|.||:.:    .:||:.|::    :|...:
Yeast    54 FRDTFKKEWEKSQELQENIKTLQDASGKLGESEAYKKAREAY----LKAQRGSTI----VGKTLK 110

  Fly   141 RVGDVLEDASKSHLAKKVTE-ELSKKAR------------------------GVSDTISDTSGKL 180
            :.|:.:|     |:|.|..| ||.|..|                        .||:.|.|
Yeast   111 KTGETME-----HIATKAWESELGKNTRKAAAATAKKLDESFEPVRQTKIYKEVSEVIDD----- 165

  Fly   181 GQTSAFQA-ISNTTTTIKKEMDSASIENRVYRAPAKLRKRVQLVMSDSD---RVVEPNTEATGME 241
            |::|.:.. |:.....:|:|.|.||            .||.:.|.|:.|   .||..|.|:
Yeast   166 GESSRYGGFITKEQRRLKRERDLAS------------GKRHRAVKSNEDAGTAVVATNIES---- 214

  Fly   242 LHKDSKFYESWENFKNNNTYVNKVLDWKVK-YDESENPVIRASRLLTDKVSDVMGGLFSKTELSE 305
              |:| |.:..|:||........:...|.| :||||||:|...|.:|:||    ||.|::||.|.
Yeast   215 --KES-FGKKVEDFKEKTVVGRSIQSLKNKLWDESENPLIVVMRKITNKV----GGFFAETESSR 272

  Fly   306 TMTELVKIDPSFDQKDFLRDCETDIIPNILESIVRGDLEILKDWCFESTFNIIANPIKEAKKAGV 370
            ..::...:||:|..:.|.|.....|:|.|||:.|:||:::||.|..|:.||:.|...|..|:..|
Yeast   273 VYSQFKLMDPTFSNESFTRHLREYIVPEILEAYVKGDVKVLKKWFSEAPFNVYAAQQKIFKEQDV 337

  Fly   371 YLDSKILDIENIELAMGKVM--EQGPVLIITFQAQQIMCVRDQKS-QVVEGDPEKVMRVHYVWVL 432
            |.|.:||||..:|:...|::  :..|||::..:||:|...|.:|: ::..||...::...|..|.
Yeast   338 YADGRILDIRGVEIVSAKLLAPQDIPVLVVGCRAQEINLYRKKKTGEIAAGDEANILMSSYAMVF 402

  Fly   433 CRDRNEL--NPKAAWRLMELSANSSEQF 458
            .||..::  :....|:::|.....|.||
Yeast   403 TRDPEQIDDDETEGWKILEFVRGGSRQF 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11779	NP_650786.2	3a0801s03tim44	78..449	CDD:130057	121/405 (30%)
CG11779	NP_650786.2	Tim44	304..452	CDD:282178	48/152 (32%)
TIM44	NP_012242.1	3a0801s03tim44	56..421	CDD:130057	121/405 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343972
Domainoid	1	1.000	91	1.000	Domainoid score	I1759
eggNOG	1	0.900	-	-		E1_KOG2580
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4631
Inparanoid	1	1.050	166	1.000	Inparanoid score	I1032
Isobase	1	0.950	-	0	Normalized mean entropy	S1602
OMA	1	1.010	-	-		QHG52906
OrthoFinder	1	1.000	-	-		FOG0003783
OrthoInspector	1	1.000	-	-		oto99719
orthoMCL	1	0.900	-	-		OOG6_102237
Panther	1	1.100	-	-	LDO	PTHR10721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1521
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740