Protein Alignment Cyp12a4 and ERG11

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 517
• Identity: 126/517 - (24%)
• Similarity: 209/517 - (40%)
• Gaps: 132/517 - (25%)

  Fly    72 MELMEMFEAMRQDYGDIF-FMPGIMGNPPFLSTH-NPQDFEVVFRNEGVWPNRPGNYTLLYHREE 134
            |:..|.||..::.||||| |:  ::|.  .::.: .|:..|.||..:....:....|..|
Yeast    74 MKPYEFFEECQKKYGDIFSFV--LLGR--VMTVYLGPKGHEFVFNAKLADVSAEAAYAHL----- 129

  Fly   135 YRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLE 199
                       ..|..||          .|:....|.||..:|      :||:..|      |.|
Yeast   130 -----------TTPVFGK----------GVIYDCPNSRLMEQK------KFVKGAL------TKE 161

  Fly   200 APDDFIDTI----------------NRWTLESVSVVALDKQLGLLKNS----NKESEALKLFHYL 244
            |...::..|                |..|..::.|:....::.:...|    .||..|     .|
Yeast   162 AFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRA-----KL 221

  Fly   245 D-EFFIVSIDLEMKPSPWRYIKTPKL------KR--LMRALDGIQEVTLAYVDEAIERLDKEAKE 300
            | :|..:..||:...:|..:: .|.|      ||  ..:|:.|      .|:....||
Yeast   222 DTDFAYLYSDLDKGFTPINFV-FPNLPLEHYRKRDHAQKAISG------TYMSLIKER------- 272

  Fly   301 GVVRPEN---EQSVLEKLLK----------VDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKN 352
               |..|   ::.:::.|:|          .|:::|.:: :.:||.|..|:::|...:||.||:.
Yeast   273 ---RKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLL-IGVLMGGQHTSAATSAWILLHLAER 333

  Fly   353 PEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVL--SGY 415
            |:.|..|.||.|:||.....|.|...::.:|.|...|||:.|:|..:....|.:.:|..:  :.|
Yeast   334 PDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSY 398

  Fly   416 RVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKS----------TNPF 470
            .:|||.:|.:.|.....||||||.|.:|...||   .|||.|.....|...          ::|
Yeast   399 VIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRW---NKDSASSYSVGEEVDYGFGAISKGVSSP- 459

  Fly   471 VFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFR----SALINLPNIPLK 528
             :||||.|...|:|:.....:|.:..:..||  .::::||......    ::::.||..|.|
Yeast   460 -YLPFGGGRHRCIGEHFAYCQLGVLMSIFIR--TLKWHYPEGKTVPPPDFTSMVTLPTGPAK 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	121/505 (24%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	122/508 (24%)