Protein Alignment Cyp12a4 and cyp11a1.1

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_694485.2
• Gene: cyp11a1.1 / 80374
• ZFINID: ZDB-GENE-010306-1
• Length: 509
• Species: Danio rerio
• Alignment Length: 554
• Identity: 146/554 - (26%)
• Similarity: 234/554 - (42%)
• Gaps: 109/554 - (19%)

  Fly    25 RWQTNVATAEAREDS--EWLQAK--------------PFEQIPRLNMWALSMKMSMPGGKYKNME 73
            ||....|..:....|  ..||.|              ||.:||               |:::|..
Zfish     3 RWNVTFARLDQSLSSLKNLLQVKVTRSGRAPQNSTVQPFNKIP---------------GRWRNSL 52

  Fly    74 LMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHN----------------------PQDFEVVFRNE 116
            |..:          .|...|.:.|...:..||                      |:|..::|:.|
Zfish    53 LSVL----------AFTKMGGLRNVHRIMVHNFKTFGPIYREKVGIYDSVYIIKPEDGAILFKAE 107

  Fly   117 GVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQV 181
            |..|||........:| :||...|    ||:..:||.|...|.::|..|:.||....:...:.:|
Zfish   108 GHHPNRINVDAWTAYR-DYRNQKY----GVLLKEGKAWKTDRMILNKELLLPKLQGTFVPLLEEV 167

  Fly   182 NQEFVQRI-LELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLG-LLKNSNKESEALKLFHYL 244
            .|:||.|: .::......:...|....:.:::|||||.|...::|| ||.|.:.|.:     |::
Zfish   168 GQDFVARVNKQIERSGQKQWTTDLTHDLFKFSLESVSAVLYGERLGLLLDNIDPEFQ-----HFI 227

  Fly   245 D----EFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRP 305
            |    .|...|..|.:.|...|.|.:...|..:.|.|||    ....|..|:.:.|:.||   .|
Zfish   228 DCVSVMFKTTSPMLYLPPGLLRSIGSNIWKNHVEAWDGI----FNQADRYIQNIFKQWKE---NP 285

  Fly   306 ENE---QSVLEKLLKVDR-KVATVMA--MDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVM 364
            |..   ..||..||..|: .:..:.|  .:::..|||:.:.|....|..||:.|:.|..||.|:.
Zfish   286 EGNGKYPGVLAILLMQDKLSIEDIKASVTELMAGGVDSVTFTLLWTLYELARQPDLQDELRAEIS 350

  Fly   365 KVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLN 429
            ........:..: .:|.:|.|:|.:||:.||||:.:...|.:..|.|:..|.:||||.|.: .:.
Zfish   351 AARIAFKGDMVQ-MVKMIPLLKAALKETLRLHPVAMSLPRFITEDTVIQNYHIPAGTLVQL-GVY 413

  Fly   430 ALTRD-EYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELE 493
            |:.|| ::||:..::.|.||:.|.:..              |..|.||||||.|:|:||.|.|::
Zfish   414 AMGRDHQFFPKPEQYCPSRWISSKRQY--------------FKSLGFGFGPRQCLGRRIAETEMQ 464

  Fly   494 LGTARLIRNFNVEFNYPTENAFRSALINLPNIPL 527
            :....::.||.:|.....|...:..|:.:|..|:
Zfish   465 IFLIHMLENFRIEKQKQIEVRSKFELLLMPEKPI 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	132/481 (27%)
cyp11a1.1	NP_694485.2	cytochrome_P450	75..498	CDD:477761	126/455 (28%)