Protein Alignment Cyp12a4 and cyp27a1.2

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: XP_073769098.1
• Gene: cyp27a1.2 / 795106
• ZFINID: ZDB-GENE-081104-511
• Length: 580
• Species: Danio rerio
• Alignment Length: 523
• Identity: 150/523 - (28%)
• Similarity: 256/523 - (48%)
• Gaps: 65/523 - (12%)

  Fly    29 NVATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKN-MELMEMFEAMRQDYGDIFFMP 92
            |.|.|.........:.|....:|.:.::.:..:|...|  |.| :..:::::  :|.||.::.:.
Zfish   100 NAAAASVSVQDGHRKLKTEADLPEIKIFTMLYQMLFKG--YLNSVHELQLYQ--KQVYGPLWKIN 160

  Fly    93 GIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDF 157
            .  ||...:|..:.:..|.:.|.:..:|.| |..||.....:.|...|    |....:|:.|...
Zfish   161 A--GNLQGISISSVELLEELLRKDEKYPCR-GYMTLWTEHRDLRGISY----GPFTEEGEKWYKL 218

  Fly   158 RTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRD-PDTLEAPDDFIDTINRWTLESVSVVAL 221
            |.|:|..::.||:...|...::.|..:|::||..||: ..|.:...:..:.:.|::||.::.:..
Zfish   219 RAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLEGIASILF 283

  Fly   222 DKQLGLLKNSNKE--SEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTL 284
            :.::|.|:   ||  :|..|..:::.:.|..|:.:.:.|: |.....|..::.:...|||.:...
Zfish   284 ETRIGCLE---KEIPAETQKFINFIAQMFTYSMHVALLPN-WTRKYFPFWQKYIDGWDGIFKFGT 344

  Fly   285 AYVDEAIERLDKEAKEGVVRPENEQSVLEKLL-------KVDRKVATVMAMDMLMAGVDTTSSTF 342
            ..:|..:|.:.|       |.:..|.|..:.|       |:.||.......::|:||||:||:|.
Zfish   345 KMIDMKMEAIQK-------RVDTNQDVAGEYLTYLLSNGKISRKDVYGSVSELLLAGVDSTSNTM 402

  Fly   343 TALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLA 407
            ...|..|:|:||.|..|.:||.|||.:.... |...:.::|:|:|.|||:.||:|::..|:|::|
Zfish   403 LWALYLLSKDPEAQETLYQEVTKVLKDDRIP-TAEEVNSMPFLKAVIKETLRLYPVVPVNSRLIA 466

  Fly   408 RDAVLSG-YRVPAGT------YVNIVPLNALTRDE-YFPQASEFLPERWLRSPKDSESKCPANEL 464
            ...|:.| |..|..|      ||       ::||| .||:..:|.||||||   |..::
Zfish   467 ETEVVIGEYFFPKKTTFTLCHYV-------ISRDEKVFPEPQKFKPERWLR---DGRTR------ 515

  Fly   465 KSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPT----ENAFRSALINLPNI 525
              .|||..:|||||.|.|||:||.|:|:.|..||||:.|.:..: ||    :..|||..:.:.|.
Zfish   516 --PNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPD-PTVGEVKANFRSLHMYIRNY 577

  Fly   526 PLK 528
            .||
Zfish   578 QLK 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	139/467 (30%)
cyp27a1.2	XP_073769098.1	None