DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a4 and cyp27b1

DIOPT Version :9

Sequence 1:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001298720.1	Gene:	cyp27b1 / 793309	ZFINID:	ZDB-GENE-111005-2	Length:	505	Species:	Danio rerio

Alignment Length:	556	Identity:	146/556 - (26%)
Similarity:	260/556 - (46%)	Gaps:	90/556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKV--RSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSM 64
            |||  ||||.|         |...:||            ::.::|.|..|:..|.        .|
Zfish     9 LKVTGRSALPL---------LRFAERW------------ADVIRAPPTPQVKTLE--------QM 44

  Fly    65 PGGK----YKNMELMEMFEAM-------RQDYGDIFFMPGIMGNPPFLSTH--NPQDFEVVFRNE 116
            ||..    .:::.:...|..:       ||.||.::  ....|  |.|:.|  .|:..:.|.|.|
Zfish    45 PGPSPARFIRDLFMKRGFSRLHQLQLEGRQKYGPMW--KASFG--PILTVHVAEPELIQQVLRQE 105

  Fly   117 GVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQV 181
            |..|.|    :.|...::||....:| .|::..:|:.|...|::::..:::|:.|..|...::.|
Zfish   106 GQHPVR----SELSSWKDYRALRGEG-YGLLTAEGEEWQCVRSLLSKHMLRPQAVEAYDGALNAV 165

  Fly   182 NQEFVQRILELRDPDTLEAPDDFIDTIN----RWTLESVSVVALDKQLGLLKNSNKESEALKLFH 242
            ..:.:|: |:||   :.|:....:..|:    |:.||.:|.|..:.::|.| ::....|..:...
Zfish   166 VSDLLQK-LKLR---SQESSSRIVSDISAEFYRFGLEGISSVLFESRIGCL-DAVVPVETERFIQ 225

  Fly   243 YLDEFFIVSIDLEMKPSPWRYIKTPK-LKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPE 306
            .::..|:::: |.|....|.:...|| .....|..|.:.|....::|   :||.:|.::.....:
Zfish   226 SINTMFVMTL-LTMAMPQWLHRLLPKPWDTFCRCWDVMFEFAKGHID---QRLQEEKQKLECGEQ 286

  Fly   307 NEQSVLEKLL-KVDRKVATVMA--MDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLP 368
            .|...|...| :....:.:|.:  .::|:|||||.|||.:..|..|:::|:.|..||:||:.|:
Zfish   287 LEGRYLTYFLSQAGLPLTSVYSNVTELLLAGVDTISSTLSWSLYELSRHPDVQTALRDEVLSVM- 350

  Fly   369 NKNSEFTEAS-MKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALT 432
             |:....:|| :..:|.|:|.:||..||:|:|..||||:.:|..:.||.:|..|.:.:... |.:
Zfish   351 -KDRSVPQASDVAAMPLLKAVVKEILRLYPVIPANARVINKDIEVGGYVIPKNTLITLCHY-ATS 413

  Fly   433 RD-EYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGT 496
            || :.|.....|.|:||            .:....::|:..:|||.|.|.|:|:||.|:|:.|..
Zfish   414 RDPQQFRDPDSFRPQRW------------GDRSDRSHPYATVPFGVGKRSCIGRRIAELEVYLAL 466

  Fly   497 ARLIRNFNVE---FNYPTENAFRSALINLPNIPLKF 529
            :|::.:|.:|   .|.......|:.|:....|.|:|
Zfish   467 SRILMHFTMEPVRENDTVHPMTRTLLVPERQIDLRF 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	128/480 (27%)
cyp27b1	NP_001298720.1	p450	45..493	CDD:278495	126/480 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.980