DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a4 and cyp11c1

DIOPT Version :9

Sequence 1:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_017206857.1	Gene:	cyp11c1 / 791124	ZFINID:	ZDB-GENE-070828-1	Length:	701	Species:	Danio rerio

Alignment Length:	526	Identity:	140/526 - (26%)
Similarity:	225/526 - (42%)	Gaps:	82/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 AKPFEQIPRL--NMWALSMKMSMPG---GKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLST 103
            |:.|::||..  |.|...::....|   ..:|:||  |.|..:...|.:      .:|:...::.
Zfish   219 ARLFQEIPDTGSNGWMNLLRFWRDGRFSRMHKHME--ESFRRLGPIYRE------HLGSQSSVNI 275

  Fly   104 HNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQP 168
            ..|.|...:||:||:.|.|........|||..|..     .||....|..|...|.::|..:|..
Zfish   276 MLPMDTGELFRSEGLHPRRMTLQPWATHRETRRHS-----KGVFLKNGTEWRADRLLLNREVMVS 335

  Fly   169 KNVRLYYKKMSQVNQEFVQRILELRDPDTLE-----------APDDFIDTINRWTLESVSVVALD 222
            .:|..:...:.:|.|:|.:.:......|..|           :||.|     |:.||:...|...
Zfish   336 SSVHRFLPLLDEVAQDFCRSLRRRVQADGFEKAGQHTLTLDPSPDLF-----RFALEASCHVLYG 395

  Fly   223 KQLGLLKN-SNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAY 286
            :::||..: .:.|||.          ||.:::..:..:|......|:|...:||.......| |:
Zfish   396 ERIGLFSSCPSDESER----------FISAVERMLATTPPLLYLPPRLLLRLRASLWTTHAT-AW 449

  Fly   287 VD---EAIERLDKEAKEGVVRPE-----NEQSVLEKLLKVDR---KVATVMAMDMLMAGVDTTSS 340
            .|   .|.:|:.:..:....||.     :...||.||::..:   ::......:::..|||||:.
Zfish   450 DDIFSHAEQRIQRSYQRLQARPSAAPDCSFPGVLGKLMEAGQLSLELIRANITELMAGGVDTTAV 514

  Fly   341 TFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEAS------MKNVPYLRACIKESQRLHPLI 399
            .....|..||:||:.|..:|.:|:       |.:.:||      ::..|.|:..|||:.||:|:.
Zfish   515 PLQFALFELARNPDVQECVRAQVL-------SSWQQASGDPLKALQGAPLLKGTIKETLRLYPVG 572

  Fly   400 VGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRD-EYFPQASEFLPERWLRSPKDSESKCPANE 463
            :...|...||.||..|.|||||.|.:. |..|.|. |.|.:...|.|.||   ..|:::
Zfish   573 ITVQRYPVRDIVLQNYHVPAGTLVQVC-LYPLGRSAEVFSRPECFDPSRW---SADADA------ 627

  Fly   464 LKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLK 528
             .|...|..|.||||.|.|||:||.|.|::|....::|.|.:..:...|.:.:..||..|..|.:
Zfish   628 -GSAGGFRSLAFGFGSRQCVGRRIAENEMQLLLMHILRTFKLTVSSTEELSTKYTLILQPECPPR 691

  Fly   529 FKFIDL 534
            ..|..|
Zfish   692 ITFSTL 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	130/488 (27%)
cyp11c1	XP_017206857.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820