Protein Alignment Cyp12a4 and cyp46a1.3

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_001027517.1
• Gene: cyp46a1.3 / 613109
• XenbaseID: XB-GENE-969052
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 496
• Identity: 105/496 - (21%)
• Similarity: 206/496 - (41%)
• Gaps: 114/496 - (22%)

  Fly    81 MRQDYGDIFFMPGIMGNPP---FLSTHNPQDFEVVFRNEGV------WPNRPGNYTLL--YHR-- 132
            |:.|:     :||    ||   |...|:|....::..|..:      |..:.|....:  .||
 Frog    34 MKYDH-----IPG----PPRDSFFLGHSPTMLRLMKNNLLMYDHFLGWVQKYGPVVRINGLHRVI 89

  Fly   133 ---------------EEYRKD-FYQGVMGV--IPTQGK---------PWGDFRTVVNPV------ 164
                           .:|.|| ||..:..:  :...||         .|...|.:::|.
 Frog    90 ILVVSPEAVKELLMSPKYSKDKFYDVIANMFGVRFMGKGLVTDRDYDHWHKQRRIMDPAFSRTYL 154

  Fly   165 --LMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGL 227
              ||.|.|.:.         :|.:::::|..|.   :......|.::|.||:.:..||...:|..
 Frog   155 MGLMGPFNEKA---------EELMEKLMEKADG---KCEIKMHDMLSRLTLDVIGKVAFGMELNS 207

  Fly   228 LKNS-NKESEALKLFHYLDEFFIVSIDLEMKPSPWRY--IKTPKLKRLMRALDGIQEVTLAYVDE 289
            |.:. ....:|:.|        ::...:||:....||  .|...::::..::..:::..    .|
 Frog   208 LNDDLTPFPKAISL--------VMKGIVEMRNPMVRYSLAKRGFIRKVQESIRLLRQTG----KE 260

  Fly   290 AIERLDKEAKEGVVRPENEQSVLEKLLK-------VDRKVATVMAMDMLMAGVDTTSSTFTALLL 347
            .|||..|:.::|...|.:   :|.::||       .|.::.....:...:||.:||::..:.:::
 Frog   261 CIERRQKQIQDGEEIPVD---ILTQILKGAAMEEECDPEILLDNFVTFFIAGQETTANQLSFVVM 322

  Fly   348 CLAKNPEKQARLREEVMKVLPNKNS-EFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAV 411
            .|.:|||...:.:.|:.:|:.:|.. |:.:  :..:.||...:||:.||:|...|.:|.|..|.|
 Frog   323 ELGRNPEILEKAQAEIDEVIGSKRDIEYED--LGKLQYLSQVLKETLRLYPTAPGTSRGLTEDMV 385

  Fly   412 LSGYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFV-FLPF 475
            :.|.:||....:.:........::|:.....|.|:|:  ||            .:..|:. :.||
 Frog   386 IDGVKVPENVTIMLNSYIMGRMEQYYSDPLTFNPDRF--SP------------DAPKPYYSYFPF 436

  Fly   476 GFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFR 516
            ..|||.|:|:...:||.::..|:|::.:  ||......:|:
 Frog   437 SLGPRSCIGQVFSQMEAKVVMAKLLQRY--EFELAEGQSFK 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	104/495 (21%)
cyp46a1.3	NP_001027517.1	CYP46A1-like	66..490	CDD:410706	95/455 (21%)