DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12a4 and cyp11a2

DIOPT Version :9

Sequence 1:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_021329545.1	Gene:	cyp11a2 / 563363	ZFINID:	ZDB-GENE-130911-1	Length:	512	Species:	Danio rerio

Alignment Length:	556	Identity:	155/556 - (27%)
Similarity:	241/556 - (43%)	Gaps:	102/556 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SQKATLSLATQKRWQTNVATAEAREDSEWLQ---AKPFEQIPRLNMWALSMK----MSMPGGKYK 70
            |.:...|:::.|.....:.|...|..:..||   .:||.:||  ..|..|:|    .:..||
Zfish     7 SARLDQSVSSLKHLLQVIVTRSGRAPAIGLQDSTVRPFNEIP--GQWRNSLKSVFAFAKMGG--- 66

  Fly    71 NMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHN---PQDFEVVFRNEGVWPNRPGNYTLLYHR 132
               |..:...|..::..  |.|.......|..:.|   |:|..::|:.||.:|.|........:|
Zfish    67 ---LRNIHRIMVHNFNT--FGPIYREKVGFYESVNIIKPEDAAILFKAEGHYPKRLTIDAWTAYR 126

  Fly   133 EEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDT 197
             :||...|    ||:...|:.|...|.::|..::.||....:...:.:|.|:||.|:.:     .
Zfish   127 -DYRNRKY----GVLLKDGEDWKSNRIILNKEVISPKVQGNFVPLLDEVGQDFVARVNK-----K 181

  Fly   198 LEAPDDFIDTINRWT-----------LESVSVVALDKQLGLLKNSNKESEALKLFHYLD---EFF 248
            :|....     |:||           |||||.|...::|||            |..|:|   :.|
Zfish   182 IERSGQ-----NQWTTDLSHELFKFALESVSAVLYGERLGL------------LLDYIDPDSQRF 229

  Fly   249 IVSIDLEMK-PSPWRYIKTPKLKRLMR---------ALDGIQEVTLAYVDEAIERLDKEAKEGVV 303
            |..|.|..| .||..|: .|.|.|.:|         |.|||    ....|..|:.:.::.::
Zfish   230 IDCITLMFKTTSPMLYL-PPGLLRPIRSKIWRNHVEAWDGI----FNQADRCIQNIYRQLRK--- 286

  Fly   304 RPENE---QSVLEKLLKVDR-KVATVMA--MDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREE 362
            .||..   ..||..||.:|: .:..:.|  .:::..|||||:.|....|..||:||:.|..:|.|
Zfish   287 NPEGNGKYTGVLASLLMLDKLSIEDIKASVTELMAGGVDTTAITLLWTLYELARNPDLQEEIRAE 351

  Fly   363 VMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVP 427
            :.........:..: .:|.:|.::..:||:.||||:.|...|.:..|.|:..|.:||||.|.: .
Zfish   352 ISAARIASKGDMVQ-MLKMIPLVKGTLKETLRLHPVAVSLQRYITEDIVIQKYHIPAGTLVQL-G 414

  Fly   428 LNALTRD-EYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEME 491
            |.|:.|| :.||...::||.||:.|              ..:.|..|.||||||.|:|:||.|.|
Zfish   415 LYAMGRDHQVFPNPEQYLPSRWVNS--------------QNHYFKSLSFGFGPRQCLGRRIAETE 465

  Fly   492 LELGTARLIRNFNVEFNYPTENAFRSALINLPNIPL 527
            ::|....::.||.:|.....|......||.||..|:
Zfish   466 MQLFLIHMLENFRIEKQRQMEVKSMFELILLPEKPI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	139/490 (28%)
cyp11a2	XP_021329545.1	p450	69..505	CDD:306555	138/486 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820