Protein Alignment Cyp12a4 and cyp11a1.2

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: XP_691817.1
• Gene: cyp11a1.2 / 563363
• ZFINID: ZDB-GENE-130911-1
• Length: 512
• Species: Danio rerio
• Alignment Length: 556
• Identity: 155/556 - (27%)
• Similarity: 241/556 - (43%)
• Gaps: 102/556 - (18%)

  Fly    13 SQKATLSLATQKRWQTNVATAEAREDSEWLQ---AKPFEQIPRLNMWALSMK----MSMPGGKYK 70
            |.:...|:::.|.....:.|...|..:..||   .:||.:||  ..|..|:|    .:..||
Zfish     7 SARLDQSVSSLKHLLQVIVTRSGRAPAIGLQDSTVRPFNEIP--GQWRNSLKSVFAFAKMGG--- 66

  Fly    71 NMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHN---PQDFEVVFRNEGVWPNRPGNYTLLYHR 132
               |..:...|..::..  |.|.......|..:.|   |:|..::|:.||.:|.|........:|
Zfish    67 ---LRNIHRIMVHNFNT--FGPIYREKVGFYESVNIIKPEDAAILFKAEGHYPKRLTIDAWTAYR 126

  Fly   133 EEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDT 197
             :||...|    ||:...|:.|...|.::|..::.||....:...:.:|.|:||.|:.:     .
Zfish   127 -DYRNRKY----GVLLKDGEDWKSNRIILNKEVISPKVQGNFVPLLDEVGQDFVARVNK-----K 181

  Fly   198 LEAPDDFIDTINRWT-----------LESVSVVALDKQLGLLKNSNKESEALKLFHYLD---EFF 248
            :|....     |:||           |||||.|...::|||            |..|:|   :.|
Zfish   182 IERSGQ-----NQWTTDLSHELFKFALESVSAVLYGERLGL------------LLDYIDPDSQRF 229

  Fly   249 IVSIDLEMK-PSPWRYIKTPKLKRLMR---------ALDGIQEVTLAYVDEAIERLDKEAKEGVV 303
            |..|.|..| .||..|: .|.|.|.:|         |.|||    ....|..|:.:.::.::
Zfish   230 IDCITLMFKTTSPMLYL-PPGLLRPIRSKIWRNHVEAWDGI----FNQADRCIQNIYRQLRK--- 286

  Fly   304 RPENE---QSVLEKLLKVDR-KVATVMA--MDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREE 362
            .||..   ..||..||.:|: .:..:.|  .:::..|||||:.|....|..||:||:.|..:|.|
Zfish   287 NPEGNGKYTGVLASLLMLDKLSIEDIKASVTELMAGGVDTTAITLLWTLYELARNPDLQEEIRAE 351

  Fly   363 VMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVP 427
            :.........:..: .:|.:|.::..:||:.||||:.|...|.:..|.|:..|.:||||.|.: .
Zfish   352 ISAARIASKGDMVQ-MLKMIPLVKGTLKETLRLHPVAVSLQRYITEDIVIQKYHIPAGTLVQL-G 414

  Fly   428 LNALTRD-EYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEME 491
            |.|:.|| :.||...::||.||:.|              ..:.|..|.||||||.|:|:||.|.|
Zfish   415 LYAMGRDHQVFPNPEQYLPSRWVNS--------------QNHYFKSLSFGFGPRQCLGRRIAETE 465

  Fly   492 LELGTARLIRNFNVEFNYPTENAFRSALINLPNIPL 527
            ::|....::.||.:|.....|......||.||..|:
Zfish   466 MQLFLIHMLENFRIEKQRQMEVKSMFELILLPEKPI 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	137/480 (29%)
cyp11a1.2	XP_691817.1	cytochrome_P450	78..501	CDD:477761	136/475 (29%)