Protein Alignment Cyp12a4 and cyp27a2

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: XP_686522.4
• Gene: cyp27a2 / 558239
• ZFINID: ZDB-GENE-120215-110
• Length: 573
• Species: Danio rerio
• Alignment Length: 585
• Identity: 158/585 - (27%)
• Similarity: 263/585 - (44%)
• Gaps: 101/585 - (17%)

  Fly    17 TLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWALSM-----KMSMPGGKYKNMELME 76
            |.|..|:..:.....:|.||:.|    :.|....|.:||...::     ..:..|.||...:.|
Zfish    18 THSRKTRPEFDRRHLSASARQSS----SDPLRHTPVVNMLISALVKADRLAAQIGRKYAPFQEM- 77

  Fly    77 MFEAMRQDYGDIFF---------------MPG-----------IMG----------------NPP 99
            :...::...||:..               :||           :.|                .|.
Zfish    78 IARTLKSQTGDVDLQSANTITGRYKTKDDLPGPNLATTVYWLFVKGYADKSHAMQVEHKRLYGPI 142

  Fly   100 FLSTHNPQDFEV-----------VFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKP 153
            :.|...|  |:|           |.|.||.:|.|    |.|.|..||| |......|:....|..
Zfish   143 WRSRFGP--FDVINVAGADLIAQVIRQEGRYPVR----TDLPHWREYR-DMRGQAYGIHVDTGPE 200

  Fly   154 WGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQR--ILELRDPDTLEAPDDFIDTINRWTLESV 216
            |...|:.:||.:::.|.|..|...:.:|..:.:||  :|.||.||.:.. .|....:.::..|.:
Zfish   201 WYRIRSALNPKMLKLKEVTAYAPIIHEVVSDLLQRLELLRLRSPDQITV-SDLASELYKFGFEGI 264

  Fly   217 SVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQE 281
            |.:..:.:||.|: ....::.|:....::|...:|..:...|...|:| .|..||.::|.|.:.:
Zfish   265 SSILFETRLGCLQ-EEIPTDTLRFISAVNEMLALSETVLFFPRWTRHI-FPFWKRFVQAWDELYD 327

  Fly   282 VTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLKVDRKVAT----VMAMDMLMAGVDTTSSTF 342
            |....:|:.:    .|.::.|.|.|..:.:....|....|::.    :...::|:.||||||:|.
Zfish   328 VARHLIDKKV----NEIRDQVARGEEVEGMYLTYLLSSNKLSLGEVYISLTELLLGGVDTTSNTL 388

  Fly   343 TALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARV-L 406
            :..|..||:|||.|.||..|::.|.|||....|: .:..:||::|.|||..|::|::.||.|: :
Zfish   389 SWTLYHLARNPEIQKRLHNEIVSVCPNKKVPNTD-DLTKMPYMKAVIKEILRMYPVVPGNGRLTV 452

  Fly   407 ARDAVLSGYRVPAGTYVNIVPLNALTRDE-YFPQASEFLPERWLRSPKDSESKCPANELKSTNPF 470
            ..|.|:..|..|..|..::... |::.|| .||.|..|:||||:|   ||.|:      ...:|:
Zfish   453 DSDIVVDNYWFPKKTQFHLCHY-AVSHDENNFPDAERFVPERWIR---DSPSR------SQHHPY 507

  Fly   471 VFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNV--EFNYPT-ENAFRSALINLPNIPLKFKFI 532
            ..:|||.|.|.|||||:.|:|:....:||::.:.|  :...|: :...|:.||  |:.|:..:||
Zfish   508 SSVPFGVGVRACVGKRVAELEMYFALSRLMQQYEVRTKAGSPSIQPKTRTLLI--PSQPIDLQFI 570

  Fly   533  532
            Zfish   571  570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	141/509 (28%)
cyp27a2	XP_686522.4	cytochrome_P450	136..567	CDD:477761	136/457 (30%)