Protein Alignment Cyp12a4 and Cyp4d8

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 475
• Identity: 109/475 - (22%)
• Similarity: 204/475 - (42%)
• Gaps: 98/475 - (20%)

  Fly    92 PGIMGNPPFLSTHNPQDFEVVFRN--------EGVWP-NR----PG----NYTLLYHREEYRKDF 139
            |.::|....:...||:.|..|.|.        :.||. ||    .|    |..||..:|...|..
  Fly    37 PPLIGAMQLMLRLNPKTFIKVGREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHP 101

  Fly   140 YQGVM------GVIPTQGKPWGDFRTVVNP-----VLMQPKNVRLYYKKMSQVNQEFVQRILELR 193
            ...|:      |::.:.||.|...|.::.|     :|.|      :.:...|.:...|||:.:..
  Fly   102 VYKVLGQWLGNGLLLSDGKVWHQRRKIITPTFHFSILEQ------FVEVFDQQSNICVQRLAQKA 160

  Fly   194 DPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSN-------KESEALKLFHYLDEFFIVS 251
            :.:|.    |...:|....|:.::..|:..::....|.:       .|..||..:.::..:..|.
  Fly   161 NGNTF----DVYRSICAAALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVE 221

  Fly   252 I--DLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERL-DKEAK-----EGVVRPENE 308
            :  .|......||.      .:|:|.:   ||.|:..:::..:.| |:::|     :..|..:..
  Fly   222 LLFTLTHPHLKWRQ------TQLIRTM---QEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRR 277

  Fly   309 QSVLEKLL------------KVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLRE 361
            .::|:.||            ::..:|.|.|     ..|.|||:|..:..|..|:::||.||::.|
  Fly   278 MALLDVLLMSTVDGRPLTNDEIREEVDTFM-----FEGHDTTTSALSFCLHELSRHPEVQAKMLE 337

  Fly   362 EVMKVL-PNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARD-----AVLSGYRVPAG 420
            |:::|| .:::...:...:..:.|:...||||.|::|.:....|.|..|     :|.....:|||
  Fly   338 EIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDGVIPAG 402

  Fly   421 TYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGK 485
            :.:.|.......:.|.||...||:|||     .::.|:        ..||..:||..|||.|:|:
  Fly   403 SEIIIGIFGVHRQPETFPNPDEFIPER-----HENGSR--------VAPFKMIPFSAGPRNCIGQ 454

  Fly   486 RIVEMELELGTARLIRNFNV 505
            :..::|:::..|:::|.:.:
  Fly   455 KFAQLEMKMMLAKIVREYEL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	109/475 (23%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	102/446 (23%)