Protein Alignment Cyp12a4 and Cyp12b2

DIOPT Version :9

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 210/505 - (41%)
• Similarity: 317/505 - (62%)
• Gaps: 11/505 - (2%)

  Fly    27 QTNVATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFM 91
            ||.:..|::|.|.:|.||:.|.:||..::..: :...||||..:|..|::|...||:.||||:.:
  Fly    33 QTQLELADSRIDEKWQQARSFGEIPGPSLLRM-LSFFMPGGALRNTNLIQMNRLMREMYGDIYCI 96

  Fly    92 PGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGD 156
            ||:||.|..:.|:||.|||:.:|||||||.|.|..:|.|:|:.:|.|.::||.|:...||:.|.|
  Fly    97 PGMMGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWAD 161

  Fly   157 FRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVAL 221
            .|..||||||:.:|||....::.|:::||:.::...|:|:|.....||.:.:..|..||:|.|||
  Fly   162 IRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQRNPETHTLTTDFHNQLKMWAFESISFVAL 226

  Fly   222 DKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAY 286
            :.::||| :.|.:..|.:|..::.:||..|...:::||.|.:.||...|:.::..|.|.::|..|
  Fly   227 NTRMGLL-SDNPDPNADRLAKHMRDFFNYSFQFDVQPSIWTFYKTAGFKKFLKTYDNITDITSNY 290

  Fly   287 VDEAIERLDKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAK 351
            ::.|:....|. .:|     ..:.|||:||:.::|||..|.|||||||:|||||....:|..||:
  Fly   291 IETAMRGFGKN-DDG-----KTKCVLEQLLEHNKKVAVTMVMDMLMAGIDTTSSACLTILYHLAR 349

  Fly   352 NPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYR 416
            ||.||.:||.|::::||......|:.:.||:|||||||||..|:..:..||.|:..:|.|||||:
  Fly   350 NPSKQEKLRRELLRILPTTKDSLTDQNTKNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQ 414

  Fly   417 VPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSE-SKCPANELKSTNPFVFLPFGFGPR 480
            ||.||.|.:..|.....|:||.|:|||:|||||:|....: ..|||  .::.||||:||||||||
  Fly   415 VPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLKSDLAPDIQACPA--ARTRNPFVYLPFGFGPR 477

  Fly   481 MCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFK 530
            .|:||||.|:|:|....||:|::.|.:...|...:.|.:|..|...::||
  Fly   478 TCIGKRIAELEIETLLVRLLRSYKVSWLPETPIEYESTIILSPCGDIRFK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	194/460 (42%)
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	194/461 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445018
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	11	10.800