DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a4 and Cyp301a1

DIOPT Version :9

Sequence 1:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	172/545 - (31%)
Similarity:	286/545 - (52%)	Gaps:	53/545 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LSLATQKRWQ-----TNVAT----AEARE--------DSEWLQAKPFEQIPRL-------NMWAL 58
            :|.|..:|.|     |.|||    |::.|        .|||..|.|:.|||..       |.|.|
  Fly    26 ISGAGSRRAQCRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPILGNTWRL 90

  Fly    59 SMKMSMP-GGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNR 122
                 || .|:|...::.::...:...||.|....|::|.|..|..::..:.|..:|:||..|.|
  Fly    91 -----MPIIGQYTISDVAKISSLLHDRYGRIVRFGGLIGRPDLLFIYDADEIEKCYRSEGPTPFR 150

  Fly   123 PGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQ 187
            |...:|:.::...||||:..:.||:...|:||.:||:.|...::|...:|.|.:.:..:.::|:.
  Fly   151 PSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITEDFLV 215

  Fly   188 RILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNK-ESEALKLFHYLDEFFIVS 251
            |...|.| :..|.|:||.:.|::|:||.:..||||.:||.|:::.| :||..::...........
  Fly   216 RCENLLD-ENQELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDAAKYALRNV 279

  Fly   252 IDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERL---DKEAKEGVVRPENEQSVLE 313
            ..||:|...|||..||...|.::.::....|.:.|:..|.|||   |...:.|      |.|::|
  Fly   280 ATLELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQSATERLKTQDPSLRAG------EPSLVE 338

  Fly   314 KLL--KVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTE 376
            |::  :.|.|:||:||:|:::.|:||.|....::|..||..|..|.::.||:.::||:.|:..|.
  Fly   339 KVILSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELKRLLPDPNTPLTI 403

  Fly   377 ASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFPQAS 441
            ..:..:.:|:..|||..|::..::||.|.|..|:|:.||:||.|.......:.....:||...|:
  Fly   404 PLLDQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPKGVQAVFPTIVTGNMEEYVTDAA 468

  Fly   442 EFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVE 506
            .|.|||||   |......|.    ..:||..||:|:|.|||:|:|..::|:::..|:|:||:.:|
  Fly   469 TFRPERWL---KPQHGGTPG----KLHPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLE 526

  Fly   507 FNY-PTENAFRSALINLPNIPLKFK 530
            :|: |.:.|.  ..:..|:.||:||
  Fly   527 YNHKPLDYAV--TFMYAPDGPLRFK 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	147/466 (32%)
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	148/472 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	9	8.970