DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a4 and Cyp49a1

DIOPT Version :9

Sequence 1:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	175/530 - (33%)
Similarity:	299/530 - (56%)	Gaps:	26/530 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SQKATLSLATQKRWQTNVATAEAREDSEWLQA-KPFEQIPRL-------NMWALSMKMSMPGGKY 69
            ||:...|:||.:   |..::..|...|....| :|:.::|..       |.|..:..:    |.|
  Fly    68 SQQPVTSVATTR---TTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLI----GTY 125

  Fly    70 KNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREE 134
            |..:|.::...:..:||.:..:.|::|:|..|...:..:...:|:.|...|:||...:|.:::.:
  Fly   126 KISDLDKVMNELHVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGD 190

  Fly   135 YRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLE 199
            .|:||:..|.|:|...|..|..||..|..:|:||:..:.|...::.:..||:.||..:|| :..|
  Fly   191 LRRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRD-EKDE 254

  Fly   200 APDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYI 264
            .|.:|:..:.:|.||||..|:||.:||.|.....| ||.::...::.||....:||::...||..
  Fly   255 LPANFLHELYKWALESVGRVSLDTRLGCLSPEGSE-EAQQIIEAINTFFWAVPELELRMPLWRIY 318

  Fly   265 KTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLKV--DRKVATVMA 327
            .|...:..::|||....:.:..:.:.:::.|.:...|:.:.|.:.|::|::::.  :||:|.::|
  Fly   319 PTKAYRSFVKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILA 383

  Fly   328 MDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKES 392
            :|:.:.||||||...::.:..|||||:||.:|.:|:.||.|::.::..:..::.:||||||:||:
  Fly   384 LDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKET 448

  Fly   393 QRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRD-EYFPQASEFLPERWLRSPKDSE 456
            .|:.|:::.|.|.|..|||::||.||.||:| |.|...::.| .|||:...|||||||:...|:
  Fly   449 LRMRPVVIANGRSLQSDAVINGYHVPKGTHV-IFPHLVVSNDPAYFPEPKRFLPERWLKQSTDA- 511

  Fly   457 SKCP-ANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALI 520
            :.|| ||:  ..:|||.||||||.|||||:|..|:||....|::.|.:.|.:| ..|..:|....
  Fly   512 AGCPHANQ--KIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYN-SGEFVYRVNST 573

  Fly   521 NLPNIPLKFK 530
            .:|..||.||
  Fly   574 YIPQSPLNFK 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	159/463 (34%)
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	158/471 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	10	9.870