DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a4 and Cyp11b3

DIOPT Version :9

Sequence 1:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_861545.1	Gene:	Cyp11b3 / 353498	RGDID:	727886	Length:	498	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	148/533 - (27%)
Similarity:	246/533 - (46%)	Gaps:	81/533 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 WQ----TNVATAEAREDSEWLQAKPFEQIPRL--NMWALSMKMSMPGGKYKNMELMEMFEAMRQD 84
            ||    |....:.|.:..:.|  ||||.||:.  |.| |.|...:.....:|:.| ||.:|. |:
  Rat    14 WQCLHRTRALGSTATQAPKTL--KPFEAIPQYSRNKW-LKMIQILREQSQENLHL-EMHQAF-QE 73

  Fly    85 YGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGV-MGVIP 148
            .|.||....  |....:|...|:|.|.:.:.|.:.|.|....:.:.|||      .:|: .||..
  Rat    74 LGPIFRHSA--GGAQIVSVMLPEDAEKLHQVESILPRRMTLESWVAHRE------LRGLRRGVFL 130

  Fly   149 TQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQ----RILE-LRDPDTLEAPDDFIDTI 208
            ..|..|...|..:||.::.||.|:.:...:..|.::||:    |:|| :....::    |....:
  Rat   131 LNGADWRFNRLQLNPNMLSPKAVQSFVPFVDVVARDFVENLKKRMLENVHGSMSM----DIQSNV 191

  Fly   209 NRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKP-SPWRYIKTPKLKRL 272
            ..:|:|:...|...::|| |...:...|:||..|.|...|..:..|...| :..|:..|...|..
  Rat   192 FNYTMEASHFVISGERLG-LTGHDLNPESLKFIHALHSMFKSTTQLMFLPKNLTRWTSTQVWKGH 255

  Fly   273 MRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPEN----EQSVLEKLLKVDRKVATVMAMDMLMA 333
            ..:.|.|.|    ||.:.|:.:.:|..||  |.::    .:.|.:..|.:|...|.  :|:::..
  Rat   256 FESWDIISE----YVTKCIKNVYRELAEG--RQQSWSVISEMVAQSTLSMDAIHAN--SMELIAG 312

  Fly   334 GVDTTSSTFTALLLCLAKNPEKQARLREEVM----KVLPNKNSEFTEASMKNVPYLRACIKESQR 394
            .||||:.:....|..||:||:.|..||:|.:    .:..|     .:.:|.::|.|||.:||:.|
  Rat   313 SVDTTAISLVMTLFELARNPDVQQALRQESLAAEASIAAN-----PQKAMSDLPLLRAALKETLR 372

  Fly   395 LHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRD-EYFPQASEFLPERWLRSPKDSESK 458
            |:|:.....|::..|.||..|.|||||.| |:.|.::.|: ..||:...::|:|||...:.
  Rat   373 LYPIGSSLERIVDSDLVLQNYHVPAGTLV-IIYLYSMGRNPAVFPRPERYMPQRWLERKRS---- 432

  Fly   459 CPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLP 523
                       |..|.||||.|.|:|:|:.|:|:.|....:::.|.||            .:...
  Rat   433 -----------FQHLAFGFGVRQCLGRRLAEVEVLLLLHHMLKIFQVE------------TLRQE 474

  Fly   524 NIPLKFKFIDLPN 536
            ::.:.::|:.:||
  Rat   475 DVQMAYRFVLMPN 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	129/474 (27%)
Cyp11b3	NP_861545.1	p450	41..494	CDD:278495	138/504 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820