Protein Alignment Cyp12a4 and CYP27C1

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_001354431.1
• Gene: CYP27C1 / 339761
• HGNCID: 33480
• Length: 537
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 145/512 - (28%)
• Similarity: 246/512 - (48%)
• Gaps: 85/512 - (16%)

  Fly    63 SMPGGK-YKNM----------ELMEMFEAMRQDYGDIF---FMPGIMGNPPFLSTHNPQDFEV-V 112
            :|||.: ..|:          .:.|:.:...::||.||   |      .|.|:.:...:|... |
Human    68 AMPGPRTLANLAEFFCRDGFSRIHEIQQKHTREYGKIFKSHF------GPQFVVSIADRDMVAQV 126

  Fly   113 FRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKK 177
            .|.||..|.|..    :....||| |......|:|..:|:.|...|:|:...:::||:|.:|..:
Human   127 LRAEGAAPQRAN----MESWREYR-DLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGE 186

  Fly   178 MSQVNQEFVQRILELRDPDTLEAPD-DFIDTIN----RWTLESVSVVALDKQLGLLKNSNKE--- 234
            ::||..:.::||..||.    :|.| :.:..:|    ::::|.|:.:..:.:||.|:||..:
Human   187 VNQVIADLIKRIYLLRS----QAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTV 247

  Fly   235 --SEALKLFH--YLDEFFIVSIDLEMK---PSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIE 292
              .|||:|..  :....:..:|...::   |.|||        ...|:.||:.:.:..:||..:.
Human   248 EYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWR--------EFCRSWDGLFKFSQIHVDNKLR 304

  Fly   293 RLDKEAKEGVVRPENEQSV---------LEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLC 348
            .:..:...|       :.|         |.:.|.:....|.|  .:||:|||||||.|.:..:..
Human   305 DIQYQMDRG-------RRVSGGLLTYLFLSQALTLQEIYANV--TEMLLAGVDTTSFTLSWTVYL 360

  Fly   349 LAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLS 413
            ||::||.|..:..|::|.|..::.. |.|.:..||.:||.:||:.||.|::.||.||...|.|:.
Human   361 LARHPEVQQTVYREIVKNLGERHVP-TAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIG 424

  Fly   414 GYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFG 478
            ||.:|.||.:.:.......:||.||:|.||.||||||.          .:|...:.|..:|||.|
Human   425 GYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRK----------GDLDRVDNFGSIPFGHG 479

  Fly   479 PRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINL--PNIPLKFKFID 533
            .|.|:|:||.|:|:.|...:|:::|.::.:..| ||..:....|  |..|:..:|::
Human   480 VRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQT-NAVHAKTHGLLTPGGPIHVRFVN 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	139/475 (29%)
CYP27C1	NP_001354431.1	CYP27C1	98..530	CDD:410740	139/475 (29%)