Protein Alignment Cyp12a4 and Cyp18a1

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 127/534 - (23%)
• Similarity: 221/534 - (41%)
• Gaps: 153/534 - (28%)

  Fly    40 EWLQAKPFEQIPRL--NMWALSM---KMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPP 99
            :|| .:.:.::.:|  ..|.|.:   .:.|  |..|:...||    :.:.||.:|
  Fly    41 QWL-VRNYRELRKLPPGPWGLPVIGYLLFM--GSEKHTRFME----LAKQYGSLF---------- 88

  Fly   100 FLSTHNPQDFEVVFRNEGVWPNRPGNYTLL---YHREEY--RKD--FYQGV--MGVIPTQGKPWG 155
              ||.......||.          .:|.::   :.|||:  |.|  |.|.:  .|:|.:.||.|.
  Fly    89 --STRLGSQLTVVM----------SDYKMIRECFRREEFTGRPDTPFMQTLNGYGIINSTGKLWK 141

  Fly   156 DFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRIL-ELRDPDTLEAPDDFIDTINRWTLESVSV- 218
            |.|..::..|.|   ..:.|  |....|:..:||: |:.         :||..::....:.|.:
  Fly   142 DQRRFLHDKLRQ---FGMTY--MGNGKQQMQKRIMTEVH---------EFIGHLHASDGQPVDMS 192

  Fly   219 ----VALDKQLGLLKNSNKES--------------EALKLF---HYLDEFFIVSIDLEMKPSPWR 262
                ||:...:..|..|.:.|              |.::||   |.:|  :|.:  ::..||
  Fly   193 PVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVD--YIPT--MQCFPS--- 250

  Fly   263 YIKTPKLKRLM-----------------RALD--GIQEVTLAYVDE----AIERLDKEAKEGVVR 304
             |.|.|.|...                 |:.|  .|:::...|:.|    ..|..|.|..:|
  Fly   251 -ISTAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDG--- 311

  Fly   305 PENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKV--- 366
             :|.:   |:|::|        .:|:..||::|..:|...:.:.:.:||::..|:::|:.:|
  Fly   312 -KNHE---EQLVQV--------IIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGR 364

  Fly   367 --LPNKNSEFTEASMKNVPYLRACIKESQRLHPLI-VGNARVLARDAVLSGYRVPAGTYVNIVPL 428
              ||      |...::.:|...:.|.||.|...:: :.......||..|:||.:|||::|  :||
  Fly   365 HRLP------TIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHV--IPL 421

  Fly   429 -NALTRD-EYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEME 491
             |::..| ..:.:..||.|.|::    |:|.|.       ..|..|:|||.|.|||:|..:..||
  Fly   422 INSVHMDPNLWEKPEEFRPSRFI----DTEGKV-------RKPEYFIPFGVGRRMCLGDVLARME 475

  Fly   492 LELGTARLIRNFNV 505
            |.|..|..:..|::
  Fly   476 LFLFFASFMHCFDI 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	117/487 (24%)
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	116/483 (24%)