DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12a4 and Cyp318a1

DIOPT Version :9

Sequence 1:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	128/571 - (22%)
Similarity:	211/571 - (36%)	Gaps:	145/571 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 WLQAKPFEQIPRLNMW-------ALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMP--GIMG 96
            |.|.|.:..|.:||.|       .|.:.:.:      |:....:.|.:.| |...|..|  .::|
  Fly    20 WQQRKCWRLIWQLNGWRGVIQQPVLWLLLCI------NLHPNSILEKVSQ-YRVHFQRPLAVLVG 77

  Fly    97 NPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVM----GVIPTQGKPWGDF 157
            ....|...:|...|.|.       |.|         |...|.|.|...    |::..:|:.|...
  Fly    78 TRVLLYIDDPAGMECVL-------NAP---------ECLDKTFLQDGFFVRRGLLHARGQKWKLR 126

  Fly   158 RTVVNPVLMQPKNVRLYYKKMSQVNQEFVQR------------------------ILELRDPDTL 198
            |..:||.... ..|..::...:.|..:.|::                        :||:.....:
  Fly   127 RKQLNPAFSH-NIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEVSCLTIM 190

  Fly   199 EAPDDFIDTINRWTLES------VSVVALDK---QLGLLKN---SNKESEALKLFHYLDEFFIVS 251
            ..|.:|....:.....|      :|.|.:.|   |:.||..   .....|:.|....|::|  |.
  Fly   191 GTPTNFTQLDDAHIAHSYKRLLEISAVRVVKPWLQIRLLHRLLAPELYEESKKCAKLLEDF--VG 253

  Fly   252 IDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVR----------PE 306
            ..:..|...|         ||..|:.|             |:..::|..|..|          ..
  Fly   254 GIVRTKHRNW---------RLRDAVGG-------------EKSGEDASNGWQRRIFIEQIFQLAA 296

  Fly   307 NEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNP-EKQARLREEVMKVLPNK 370
            |.:..||:::.        .|..|::...:|.|::....|||||.|. :.|.||..|:..::|:.
  Fly   297 NGEMTLEEIMD--------EAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDV 353

  Fly   371 NSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALT--- 432
            .....| .::.:.||.|.:.||.||...:..|.|.::||     :|:....:..|||.|::.
  Fly   354 GQVGLE-QLQQLRYLDAFVSESLRLLATVPMNLRHVSRD-----FRLAGRQHETIVPQNSIVVLD 412

  Fly   433 -----RDE--YFPQASEFLPERWL--------RSPKDSESKCPANELKSTNPFVFLPFGFGPRMC 482
                 |||  :...|.:|.|:|:|        :...||.|.....:....:.:.||||..|.|.|
  Fly   413 TFNMQRDERWWGANARQFDPQRFLDQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSC 477

  Fly   483 VGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFKFID 533
            :|:|.....:::...:||.||:.:.::..|.     |..:.||.||||..|
  Fly   478 IGRRYGLFIMKVFLVKLITNFDFQSDFELEK-----LQFVENISLKFKNAD 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	117/529 (22%)
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	112/522 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030