Protein Alignment Cyp12a4 and Cyp4d1

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 518
• Identity: 124/518 - (23%)
• Similarity: 223/518 - (43%)
• Gaps: 117/518 - (22%)

  Fly    88 IFFMPG------------IMGNPP---------FLSTH-------------------NPQDFEVV 112
            |.:|||            .:|.||         |:.|:                   ||:|.|||
  Fly    31 ISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSKDQVLKVWLGPELNVLMGNPKDVEVV 95

  Fly   113 FRNEGV--WPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYY 175
            .   |.  :.::.|.|..|   |.:.|:      |::.::|:.|...|.::.|.        .::
  Fly    96 L---GTLRFNDKAGEYKAL---EPWLKE------GLLVSRGRKWHKRRKIITPA--------FHF 140

  Fly   176 KKMSQVNQEF---VQRILELRDPDTLEAPD---DFIDTINRWTLESVSVVALDKQLGLLKNSNKE 234
            |.:.|..:.|   .:.:|...:.|.|:..|   ...|.||..|::::...|:...:....|::.|
  Fly   141 KILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINAQSNADSE 205

  Fly   235 -SEALK---------LFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDE 289
             .:|:|         :|:.|..|     ||       .|:.||..:...:||:.:.:.|...:.:
  Fly   206 YVQAVKTISMVLHKRMFNILYRF-----DL-------TYMLTPLARAEKKALNVLHQFTEKIIVQ 258

  Fly   290 AIERLDKEAK-------EGVVRPENEQSVLEKLLK--VDRKVATVM----AMDMLM-AGVDTTSS 340
            ..|.|.:|..       :..|..:.:.:.|:.||:  ||.:..:.:    .:|..| .|.|||||
  Fly   259 RREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFMFEGHDTTSS 323

  Fly   341 TFTALLLCLAKNPEKQARLREEVMKVLPN-KNSEFTEASMKNVPYLRACIKESQRLHPLIVGNAR 404
            ........:|.:||.|.:..||:..|:.| |::..:...:..:.|:..|:||:.|::|.:....|
  Fly   324 ALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGR 388

  Fly   405 VLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNP 469
            .:..|..::|..:||||.:.|.||....|:|.|.:.:.|.|||:       :....|.:|   ||
  Fly   389 KVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERF-------DVVTTAEKL---NP 443

  Fly   470 FVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEF--NYPTENAFRSALINLPNIPLKFK 530
            :.::||..|||.|:|::...:|::...|.::|::.|:|  :........:.||.....||.||
  Fly   444 YAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	121/514 (24%)
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	112/472 (24%)