DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12a4 and Cyp11a1

DIOPT Version :9

Sequence 1:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_058982.1	Gene:	Cyp11a1 / 29680	RGDID:	69325	Length:	526	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	149/548 - (27%)
Similarity:	243/548 - (44%)	Gaps:	63/548 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKVRSALSLIQSQKATLSLATQKRWQ-TNVATAEAREDSEWLQAKPFEQIPRL--NMWALSMKMS 63
            |.:||.  |::|.:..||..    || ..:||......|.....:.|.:||..  |.|.......
  Rat     6 LCLRSV--LVKSCQPFLSPV----WQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFL 64

  Fly    64 MPGGKYK-NMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYT 127
            ...|.:: :...|:.|    |.||.|:...  :||...:...:|:|...:|..||  || |..|.
  Rat    65 RENGTHRIHYHHMQNF----QKYGPIYREK--LGNMESVYILDPKDAATLFSCEG--PN-PERYL 120

  Fly   128 ----LLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQR 188
                :.||:      :||..:||:......|...|.|:|..:|.|.:::.:...:..|.|:|: :
  Rat   121 VPPWVAYHQ------YYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFI-K 178

  Fly   189 IL--ELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVS 251
            :|  .::..::.:...|..|.:.|:..||::.|...::||:|:.. .:.|:.:....:.:.|..|
  Rat   179 VLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEI-VDPESQRFIDAVYQMFHTS 242

  Fly   252 ID-LEMKPSPWRYIKTPKLKRLMRALDGI----QEVTLAYVDEAIERLDKEAKEGVVRPENEQSV 311
            :. |.|.|..:|..:|...|....|.|.|    .|.|..:..:..::.|.....|         |
  Rat   243 VPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPG---------V 298

  Fly   312 LEKLL---KVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSE 373
            |..||   |:..|.......:||..||||||.|....|..:|.|.:.|..||.||:........:
  Rat   299 LYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGD 363

  Fly   374 FTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFP 438
            ..: .::.||.|:|.|||:.||||:.|...|.:..|.||..|::||.|.|.:..........:||
  Rat   364 MAK-MVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFP 427

  Fly   439 QASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNF 503
            ..::|.|.|||            .:.::|..|.:|.||:|.|.|:|:||.|:|:.:....::.||
  Rat   428 NPNKFDPTRWL------------EKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENF 480

  Fly   504 NVEFNYPTENAFRSALINLPNIPLKFKF 531
            .:|.....:...:..||.:|..|:.|.|
  Rat   481 RIEVQSIRDVGTKFNLILMPEKPIFFNF 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	130/472 (28%)
Cyp11a1	NP_058982.1	cytochrome_P450	80..505	CDD:425388	128/463 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820