Protein Alignment Cyp12a4 and CYP27B1

DIOPT Version :9

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000776.1
• Gene: CYP27B1 / 1594
• HGNCID: 2606
• Length: 508
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 124/457 - (27%)
• Similarity: 209/457 - (45%)
• Gaps: 69/457 - (15%)

  Fly   106 PQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKN 170
            |...|.:.|.||..|.|........||.     ..|...|::..:|:.|...|:::.|:|::|:.
Human    91 PALVEELLRQEGPRPERCSFSPWTEHRR-----CRQRACGLLTAEGEEWQRLRSLLAPLLLRPQA 150

  Fly   171 VRLYYKKMSQVNQEFVQRILELRDPDTLEAPD----DFIDTINRWTLESVSVVALDKQLGLLKNS 231
            ...|...::.|..:.|:|:...|...|  .|.    |......::.||.::.|.|..:||.|: :
Human   151 AARYAGTLNNVVCDLVRRLRRQRGRGT--GPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLE-A 212

  Fly   232 NKESEALKLFHYLDEFFIVSIDLEMK---------PSPWRYIKTPKLKRLMRALDGIQEVTLAYV 287
            ....:.......:...|:.:: |.|.         |.||        .||.|..|.:    .|:.
Human   213 QVPPDTETFIRAVGSVFVSTL-LTMAMPHWLRHLVPGPW--------GRLCRDWDQM----FAFA 264

  Fly   288 DEAIERLDKEA--KEGVVRPENEQSVLEK-------LLKVDRKVATVM--AMDMLMAGVDTTSST 341
            ...:||.:.||  :.| .:||.:   ||.       |.:.:....:::  ..::|:|||||.|:|
Human   265 QRHVERREAEAAMRNG-GQPEKD---LESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

  Fly   342 FTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEAS-MKNVPYLRACIKESQRLHPLIVGNARV 405
            .:..|..|:::||.|..|..|:...|...:|.:..|: :..:|.|:|.:||..||:|::.||:||
Human   326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRV 390

  Fly   406 LARDAVLSGYRVPAGTYVNIVPLNALTRD-EYFPQASEFLPERWLRSPKDSESKCPANELKSTNP 469
            ..:|..:..|.:|..|.|.:... |.:|| ..||:.:.|.|.|||     .|...|       :|
Human   391 PDKDIHVGDYIIPKNTLVTLCHY-ATSRDPAQFPEPNSFRPARWL-----GEGPTP-------HP 442

  Fly   470 FVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFN---YPTENAFRSALINLPNIPLKFKF 531
            |..||||||.|.|:|:|:.|:||::..|:::.:|.|:..   .|.....|:.|:  |...:..:|
Human   443 FASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLV--PERSINLQF 505

  Fly   532 ID 533
            :|
Human   506 LD 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	122/453 (27%)
CYP27B1	NP_000776.1	p450	41..505	CDD:278495	122/453 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.880