DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a4 and CYP27A1

DIOPT Version :9

Sequence 1:	NP_650783.2	Gene:	Cyp12a4 / 42294	FlyBaseID:	FBgn0038681	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_000775.1	Gene:	CYP27A1 / 1593	HGNCID:	2605	Length:	531	Species:	Homo sapiens

Alignment Length:	523	Identity:	142/523 - (27%)
Similarity:	238/523 - (45%)	Gaps:	85/523 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQD- 108
            :..|:||||.......::.:.|...:..:|..:::|   .||           |.::|...||.
Human    55 RSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKA---KYG-----------PMWMSYLGPQMH 105

  Fly   109 --------FEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVL 165
                    .|.|.|.||.:|.|........||:::...:     |...|:|..|...|..:|..|
Human   106 VNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTY-----GPFTTEGHHWYQLRQALNQRL 165

  Fly   166 MQPKNVRLYYKKMSQVNQEFVQRILELR-DPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLK 229
            ::|....||....::|..:|:.|:.:|| :..:.....|.......:.||::..:..:|::|.|:
Human   166 LKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQ 230

  Fly   230 NSNKESEALKLFHYLDEFFIVSIDLEMKPS-------PWRYIKTPKLKRLMRALDGIQEVTLAYV 287
            .|..|....         |:.||.|..:.|       .|.....|..||.:...:.|.......:
Human   231 RSIPEDTVT---------FVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLI 286

  Fly   288 DEAIERLDKEAKEGVVRPENEQ--SVLEKLL---KVDRKVATVMAMDMLMAGVDTTSSTFTALLL 347
            ||.:|  |.||:.....|:..|  ..|..||   ::..:.|.....::|||||||||:|.|..|.
Human   287 DEKLE--DMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALY 349

  Fly   348 CLAKNPEKQARLREEVMKVLP----NKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLAR 408
            .|:|:||.|..|.|||:.|:|    .::.:|.     ::|.|:|.:||:.||:|::..|:|::.:
Human   350 HLSKDPEIQEALHEEVVGVVPAGQVPQHKDFA-----HMPLLKAVLKETLRLYPVVPTNSRIIEK 409

  Fly   409 DAVLSGYRVPAGT------YVNIVPLNALTRD-EYFPQASEFLPERWLRSPKDSESKCPANELKS 466
            :..:.|:..|..|      ||       ::|| ..|.:...|.|.||||:.:      ||.. :.
Human   410 EIEVDGFLFPKNTQFVFCHYV-------VSRDPTAFSEPESFQPHRWLRNSQ------PATP-RI 460

  Fly   467 TNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSA--LINLPNIPLKF 529
            .:||..:|||:|.|.|:|:||.|:|::|..||||:.:.|.. .|.....:|.  ::.:||..:..
Human   461 QHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVL-APETGELKSVARIVLVPNKKVGL 524

  Fly   530 KFI 532
            :|:
Human   525 QFL 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	135/493 (27%)
CYP27A1	NP_000775.1	p450	61..526	CDD:306555	139/514 (27%)
CYP27A1	NP_000775.1	Sterol-binding. /evidence=ECO:0000255	384..398		7/13 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.780