Protein Alignment Cyp12a4 and CYP24A1

DIOPT Version :9

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 142/500 - (28%)
• Similarity: 240/500 - (48%)
• Gaps: 66/500 - (13%)

  Fly    50 IPRLNMWAL---SMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTH--NPQDF 109
            :|....|.|   .:::...||..|..:.:..:   .:.||.||.|.  :|:  |.|.|  :|...
Human    58 LPGPTSWPLLGSLLQILWKGGLKKQHDTLVEY---HKKYGKIFRMK--LGS--FESVHLGSPCLL 115

  Fly   110 EVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLY 174
            |.::|.|..:|.|........:| :|||:.|    |::..:|:.|...|:.....||:|..|...
Human   116 EALYRTESAYPQRLEIKPWKAYR-DYRKEGY----GLLILEGEDWQRVRSAFQKKLMKPGEVMKL 175

  Fly   175 YKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALK 239
            ..|:::|..:|:.||.||  .|.....:|....:|:|:.||:.:|..:|:.|||: .|...||:.
Human   176 DNKINEVLADFMGRIDEL--CDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQ-KNAGDEAVN 237

  Fly   240 LFHYLDEFFIVSIDLEMKPSPWRYIKTP-KLKRLMR---------ALDGIQEVTLAYVDEAIERL 294
                    ||::|. .|..:..|.:.|| :|.:.:.         |.|.|.:...|.:|..:|:.
Human   238 --------FIMAIK-TMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKY 293

  Fly   295 DKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARL 359
            .::.....:.....|:.|.|      |.......::.:|.|:||:::...:|..|::||:.|.:|
Human   294 SQQPSADFLCDIYHQNRLSK------KELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKL 352

  Fly   360 REEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVN 424
            .:|:..|||.......| .::|:|||:||:|||.||.|.:....|.|.:..||..|.:|.||
Human   353 LKEIQSVLPENQVPRAE-DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGT--- 413

  Fly   425 IVPLNAL---TRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKR 486
            ::.||..   :.::.|..:|:|.|||||:            |.:..|||..||||.|.|||:|:|
Human   414 VLMLNTQVLGSSEDNFEDSSQFRPERWLQ------------EKEKINPFAHLPFGVGKRMCIGRR 466

  Fly   487 IVEMELELGTARLIRNFNVEF--NYPTENAFRSALINLPNIPLKF 529
            :.|::|.|....::|.::::.  |.|.|......|:....:|:.|
Human   467 LAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAF 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	135/474 (28%)
CYP24A1	NP_000773.2	p450	59..512	CDD:278495	141/498 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	1	0.950	-	0	Normalized mean entropy	S4812
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.720