Protein Alignment Cyp12a4 and CYP11A1

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000772.2
• Gene: CYP11A1 / 1583
• HGNCID: 2590
• Length: 521
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 146/535 - (27%)
• Similarity: 240/535 - (44%)
• Gaps: 48/535 - (8%)

  Fly    10 LIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRL--NMWALSMKMSMPGGKYK-N 71
            |::..:..||...:...:..|.|.|....|. ...:||.:||..  |.|..........|.:| :
Human    12 LVKGCQTFLSAPREGLGRLRVPTGEGAGIST-RSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVH 75

  Fly    72 MELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTL----LYHR 132
            :..::.|    |.||.|:...  :||...:...:|:|..::|::||  || |..:.:    .||:
Human    76 LHHVQNF----QKYGPIYREK--LGNVESVYVIDPEDVALLFKSEG--PN-PERFLIPPWVAYHQ 131

  Fly   133 EEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRI-LELRDPD 196
                  :||..:||:..:...|...|..:|..:|.|:..:.:...:..|:::||..: ..::...
Human   132 ------YYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAG 190

  Fly   197 TLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSID-LEMKPSP 260
            :.....|..|.:.|:..||::.|...::.|:|:.. ...||.:....:.:.|..|:. |.:.|..
Human   191 SGNYSGDISDDLFRFAFESITNVIFGERQGMLEEV-VNPEAQRFIDAIYQMFHTSVPMLNLPPDL 254

  Fly   261 WRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLL---KVDRKV 322
            :|..:|...|..:.|.|.|......|.......|   .::|.|. .:.:.:|.:||   |:..:.
Human   255 FRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWEL---RQKGSVH-HDYRGILYRLLGDSKMSFED 315

  Fly   323 ATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRA 387
            ......:||..||||||.|....|..:|:|.:.|..||.||:........:.. ..::.||.|:|
Human   316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA-TMLQLVPLLKA 379

  Fly   388 CIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRD-EYFPQASEFLPERWLRS 451
            .|||:.||||:.|...|.|..|.||..|.:||.|.|. |.:.||.|: .:|.....|.|.|||
Human   380 SIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQ-VAIYALGREPTFFFDPENFDPTRWL-- 441

  Fly   452 PKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFR 516
            .||          |:...|..|.||:|.|.|:|:||.|:|:.:....::.||.||..:.::....
Human   442 SKD----------KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTT 496

  Fly   517 SALINLPNIPLKFKF 531
            ..||.:|..|:.|.|
Human   497 FNLILMPEKPISFTF 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	128/455 (28%)
CYP11A1	NP_000772.2	CYP11A1	82..508	CDD:410736	129/459 (28%)