Protein Alignment Cyp12a4 and CYP2E1

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000764.1
• Gene: CYP2E1 / 1571
• HGNCID: 2631
• Length: 493
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 132/549 - (24%)
• Similarity: 209/549 - (38%)
• Gaps: 137/549 - (24%)

  Fly    39 SEW-LQAKPFEQIPRL-NMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFL 101
            |.| |...|| .:|.: |::.|.:|           .:.:.|..:.|.:|.:|.:  .:|:...:
Human    28 SSWNLPPGPF-PLPIIGNLFQLELK-----------NIPKSFTRLAQRFGPVFTL--YVGSQRMV 78

  Fly   102 STHNPQ-------DFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRT 159
            ..|..:       |::..|...|..|        .:|....|        |:|...|..|.|.|.
Human    79 VMHGYKAVKEALLDYKDEFSGRGDLP--------AFHAHRDR--------GIIFNNGPTWKDIRR 127

  Fly   160 VVNPVLMQPKNVRLYYKKMSQVNQEFVQR----ILE-LR-------DPDTLE--APDDFI-DTIN 209
            .....|..       |....|.|:..:||    :|| ||       ||..|.  ||.:.| |.:.
Human   128 FSLTTLRN-------YGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILF 185

  Fly   210 RWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDE-----FFIVSIDLEMKPSPW--RYIKTP 267
            |                            |.|.|.||     .::.:.:..:..:||  .|...|
Human   186 R----------------------------KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFP 222

  Fly   268 KLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEG----------------VVRPENEQSVLEKLL 316
            .   .:..|.|.....:..|.|..|.:.:..||.                :|..|.|:...|:|.
Human   223 S---FLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLY 284

  Fly   317 KVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVL-PNKNSEFTEASMK 380
            .:|.  .||...|:..||.:|||:|....||.|.|.||.:.:|.||:.:|: |::.....:  .:
Human   285 TMDG--ITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD--RQ 345

  Fly   381 NVPYLRACIKESQRLHPLIVGN-ARVLARDAVLSGYRVPAGTYVNIVPL--NALTRDEYFPQASE 442
            .:||:.|.:.|.||...|:..| .....||.:..||.:|.||.|  ||.  :.|..::.||...:
Human   346 EMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVV--VPTLDSVLYDNQEFPDPEK 408

  Fly   443 FLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVE- 506
            |.||.:|..         ..:.|.::  .|.||..|.|:|.|:.:..|||.|....::::||::
Human   409 FKPEHFLNE---------NGKFKYSD--YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462

  Fly   507 FNYPTENAFRSALINLPNIPLKFKFIDLP 535
            ...|.:.......|....||.::|...:|
Human   463 LVDPKDIDLSPIHIGFGCIPPRYKLCVIP 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	120/495 (24%)
CYP2E1	NP_000764.1	CYP2C-like	64..487	CDD:410758	119/495 (24%)