Protein Alignment Cyp12a4 and Cyp24a1

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_034126.1
• Gene: Cyp24a1 / 13081
• MGIID: 88593
• Length: 514
• Species: Mus musculus
• Alignment Length: 547
• Identity: 153/547 - (27%)
• Similarity: 248/547 - (45%)
• Gaps: 71/547 - (12%)

  Fly     4 VRSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWAL---SMKMSMP 65
            :|....|.|..::..|.|..||....|.......|.|   .:....:|....|.|   .:::...
Mouse    15 LRRLRDLGQPPRSVTSKAHVKRAPKEVPLCPLMTDGE---TRNVTSLPGPTNWPLLGSLLEIFWK 76

  Fly    66 GGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTH--NPQDFEVVFRNEGVWPNRPGNYTL 128
            ||..|..:.:..:   .:.||.||.|.  :|:  |.|.|  :|...|.::|.|...|.|......
Mouse    77 GGLKKQHDTLAEY---HKKYGQIFRMK--LGS--FDSVHLGSPSLLEALYRTESAHPQRLEIKPW 134

  Fly   129 LYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELR 193
            ..:| ::|.:.|    |::..:|:.|...|:.....||:|..:....||:::|..:|:.:|.|||
Mouse   135 KAYR-DHRNEAY----GLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFMGQIDELR 194

  Fly   194 DPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKP 258
              |......|....:|:|:.||:.:|..:|:.|||:...:| |||.        ||.:|...|..
Mouse   195 --DERGRIQDLYSELNKWSFESICLVLYEKRFGLLQKDTEE-EALT--------FIAAIKTMMST 248

  Fly   259 SPWRYIKTPKL-KRLMRALDGIQEVTLAY----------VDEAIERLDKEAKEGVVRPENEQSVL 312
            .....:...:| |||...:  .|..|||:          :|..:||..::.....:....:|..|
Mouse   249 FGKMMVTPVELHKRLNTKV--WQAHTLAWDTIFKSVKPCIDHRLERYSQQPGADFLCDIYQQDHL 311

  Fly   313 EKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEA 377
            .|      |.......::.:|.|:||:::...:|..|::||:.|.||..|:..|||:..:...|
Mouse   312 SK------KELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQRLLREIQSVLPDNQTPRAE- 369

  Fly   378 SMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNAL---TRDEYFPQ 439
            .::|:|||:||:|||.||.|.:....|.|.:..||..|.:|.||   ::.||..   :.::.|..
Mouse   370 DVRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYTLPKGT---VLTLNTQVLGSSEDNFED 431

  Fly   440 ASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFN 504
            |.:|.|||||...            |..|||..||||.|.|||:|:|:.|::|.|....:|:.:|
Mouse   432 ADKFRPERWLEKE------------KKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIIQKYN 484

  Fly   505 V--EFNYPTENAFRSALINLPNIPLKF 529
            :  ..:.|.|......|:....:|:.|
Mouse   485 IVATDSEPVEMLHLGILVPSRELPIAF 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	136/463 (29%)
Cyp24a1	NP_034126.1	CYP24A1	90..508	CDD:410738	135/461 (29%)