Protein Alignment Cyp12a4 and Cyp11b2

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_034121.4
• Gene: Cyp11b2 / 13072
• MGIID: 88584
• Length: 500
• Species: Mus musculus
• Alignment Length: 549
• Identity: 144/549 - (26%)
• Similarity: 245/549 - (44%)
• Gaps: 90/549 - (16%)

  Fly    15 KATLSLATQKRWQ----TNVATAEAREDSEWLQAKPFEQIPRL--NMWALSMKMSMPGGKYKNME 73
            :.|..:...:.||    |......|....:.||  |||.||:.  |.|...:::....|: :|:.
Mouse     4 RVTADVWLARPWQCLHRTRALGTTATLAPKTLQ--PFEAIPQYSRNKWLKMIQILREQGQ-ENLH 65

  Fly    74 LMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKD 138
            | ||.:..| :.|.||  ...:|....:|...|:|.|.:.:.|.:.|.|......:.|||
Mouse    66 L-EMHQVFR-ELGPIF--RHSVGKTQIVSVMLPEDAEKLHQVESMLPRRMHLEPWVAHRE----- 121

  Fly   139 FYQGV-MGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILE-----LRDPDT 197
             .:|: .||....|..|...|..:|..::.||.|:.:...:..|.::|::.:.|     .|...|
Mouse   122 -LRGLRRGVFLLNGPEWRLNRLRLNRNVLSPKAVQKFVPMVDMVARDFLETLKEKVLQNARGSLT 185

  Fly   198 LEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKP-SPW 261
            :    |...::..:|:|:.:.....::|||| ..:....:||..|.|...|..:..|...| |..
Mouse   186 M----DVQQSLFNYTIEASNFALFGERLGLL-GHDLSPGSLKFIHALHSMFKSTSQLLFLPKSLT 245

  Fly   262 RYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAK-------EGVVRPENEQSVLEKLLKVD 319
            |:..|...|....|.|.|.|    |.:..|.::.:|.:       .|:|    .:.:.:..|.:|
Mouse   246 RWTSTRVWKEHFDAWDVISE----YANRCIWKVHQELRLGSSQTYSGIV----AELISQGSLPLD 302

  Fly   320 RKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVM----KVLPNKNSEFTEASMK 380
            ...|.  :|::....||||:......|..||:||:.|..||:|.:    .:..|     .:.:|.
Mouse   303 AIKAN--SMELTAGSVDTTAIPLVMTLFELARNPDVQKALRQESLAAEASIAAN-----PQKAMS 360

  Fly   381 NVPYLRACIKESQRLHPLIVGN--ARVLARDAVLSGYRVPAGTYVNIVPLNALTRD-EYFPQASE 442
            ::|.|||.:||:.||:|  ||.  .|:|:.|.||..|.|||||.| ::.|.::.|: ..||:...
Mouse   361 DLPLLRAALKETLRLYP--VGGFLERILSSDLVLQNYHVPAGTLV-LLYLYSMGRNPAVFPRPER 422

  Fly   443 FLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEF 507
            ::|:|||...:.               |..|.||||.|.|:|:|:.|:|:.|....:::.|.||
Mouse   423 YMPQRWLERKRS---------------FQHLAFGFGVRQCLGRRLAEVEMMLLLHHILKTFQVE- 471

  Fly   508 NYPTENAFRSALINLPNIPLKFKFIDLPN 536
                       .:...::.:.::|:.:|:
Mouse   472 -----------TLRQEDVQMAYRFVLMPS 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	123/466 (26%)
Cyp11b2	NP_034121.4	cytochrome_P450	72..496	CDD:477761	125/477 (26%)