Protein Alignment Cyp12a4 and Cyp11a1

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_062753.3
• Gene: Cyp11a1 / 13070
• MGIID: 88582
• Length: 526
• Species: Mus musculus
• Alignment Length: 554
• Identity: 149/554 - (26%)
• Similarity: 246/554 - (44%)
• Gaps: 76/554 - (13%)

  Fly     2 LKVRSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPR------LNM---WA 57
            |.:||.  |::..:..||    ..||..|.:......:.....:.|.:||.      ||:   |.
Mouse     6 LSLRSV--LVKGCQPFLS----PTWQGPVLSTGKGAGTSTSSPRSFNEIPSPGDNGWLNLYHFWR 64

  Fly    58 LSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNR 122
            .|      |.:..:...|:.|    |.||.|:...  :|....:...:|:|..::|..||..|.|
Mouse    65 ES------GTQKIHYHQMQSF----QKYGPIYREK--LGTLESVYIVDPKDASILFSCEGPNPER 117

  Fly   123 ----PGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQ 183
                |   .:.||:      :||..:||:......|...|.|:|..:|.|..::.:...:..|.|
Mouse   118 FLVPP---WVAYHQ------YYQRPIGVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQ 173

  Fly   184 EFVQRIL--ELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDE 246
            :|: ::|  .::..::........|.:.|::.||:|.|...:::|:|:.. .:.||.:..:.:.:
Mouse   174 DFI-KVLHRRIKQQNSGNFSGVISDDLFRFSFESISSVIFGERMGMLEEI-VDPEAQRFINAVYQ 236

  Fly   247 FFIVSID-LEMKPSPWRYIKTPKLKRLMRALDGI----QEVTLAYVDEAIERLDKEAKEGVVRPE 306
            .|..|:. |.:.|..:|.::|...|....|.|.|    .|.|..:..:..::.|.....|
Mouse   237 MFHTSVPMLNLPPDFFRLLRTKTWKDHAAAWDVIFNKADEYTQNFYWDLRQKRDFSQYPG----- 296

  Fly   307 NEQSVLEKLL---KVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLP 368
                ||..||   |:..|.......:||..||||||.|....|..:|.|.:.|..||.||:....
Mouse   297 ----VLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARR 357

  Fly   369 NKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTR 433
            ....:..: .::.||.|:|.|||:.||||:.|...|....|.||..|::||.|.|.:... |:.|
Mouse   358 QAQGDMAK-MVQLVPLLKASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTLVQVASF-AMGR 420

  Fly   434 DE-YFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTA 497
            |. :||..::|.|.|||            .:.::|..|.:|.||:|.|.|:|:||.|:|:.:...
Mouse   421 DPGFFPNPNKFDPTRWL------------EKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTILLI 473

  Fly   498 RLIRNFNVEFNYPTENAFRSALINLPNIPLKFKF 531
            .|:.||.:|.....:...:.:||.:|..|:.|.|
Mouse   474 NLLENFRIEVQNLRDVGTKFSLILMPENPILFNF 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	128/460 (28%)
Cyp11a1	NP_062753.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..49		1/18 (6%)
		cytochrome_P450	79..504	CDD:477761	129/464 (28%)