Protein Alignment Cyp12a4 and cyp27a1.2

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: XP_031749759.1
• Gene: cyp27a1.2 / 116407844
• XenbaseID: XB-GENE-29093451
• Length: 546
• Species: Xenopus tropicalis
• Alignment Length: 527
• Identity: 142/527 - (26%)
• Similarity: 252/527 - (47%)
• Gaps: 69/527 - (13%)

  Fly    30 VATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGI 94
            ||.|......|..:.|.||.:|..::......:.:.|......||..::   :::||.::  ...
 Frog    57 VAGAAVGAVGEEKKMKTFEDLPGPSLLTNIYWVFLRGYILYTHELQAIY---KKNYGPMW--KST 116

  Fly    95 MGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRT 159
            :|....::..:....|.|.|.||.:|.|........||.:  :|.   .:|....:|..|...|:
 Frog   117 LGRYKTVNIADVDILETVLRQEGKYPVRIDMEVWKEHRRQ--RDL---SLGPFTEEGHKWHTLRS 176

  Fly   160 VVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAP-----DDFIDTINRWTLESVSVV 219
            |:|..:::|....||...:::|..:|:.|:.|:|.    |.|     :|..:.:.|:..|.:|.:
 Frog   177 VLNKRMLKPAEAMLYTGVVNEVVTDFLVRLEEMRS----ETPSGDMVNDIPNALYRFAFEGISYI 237

  Fly   220 ALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKP-------SPWRYIKTPKLKRLMRALD 277
            ..:.::|.|:         |......:.||.||...:|.       .||.....|..||.|.:.|
 Frog   238 LFETRIGCLE---------KQIPVETQRFIDSIGAMLKNYIFVTILPPWTNNLLPYYKRYMDSWD 293

  Fly   278 GIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLK--------VDRKVATVMAMDMLMAG 334
            .|.......::|.:::::       .|.|.::.|..:.|.        .|:::...:| ::|:||
 Frog   294 NIFAFGNKLINEKMKKIE-------ARLERDEEVQGEYLTYLISSGKLTDKEIYGSVA-ELLLAG 350

  Fly   335 VDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLI 399
            |||||:|.:..|..||:.||.|..|.:||:.|:|.:|.. |...:.::|.|||.|||:.||:|::
 Frog   351 VDTTSNTLSWALYHLAREPEIQNALYQEVIGVVPGQNIP-TSEDISSMPLLRAVIKETLRLYPVV 414

  Fly   400 VGNARVLARDAVLSG-YRVPAGTYVNIVPLNALTRDE-YFPQASEFLPERWLRSPKDSESKCPAN 462
            ..|:||....|:..| |..|..|.:.:...: ::||| .||::.:|:|:||.|     ||:.
 Frog   415 PTNSRVAVEKAITIGDYYFPKDTLIALHHYH-ISRDEKNFPESDKFIPQRWFR-----ESRV--- 470

  Fly   463 ELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRS--ALINLPNI 525
               ..|||..:|||:|.|.|||:||.|:|:.:..:|:|:.:.|..: |:....:|  .::..|:.
 Frog   471 ---KNNPFSSIPFGYGVRACVGRRIAELEMHMCLSRIIKKYEVRPD-PSGAEIKSMARIVLTPHK 531

  Fly   526 PLKFKFI 532
            |:..:|:
 Frog   532 PINLQFL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	130/469 (28%)
cyp27a1.2	XP_031749759.1	cytochrome_P450	106..535	CDD:477761	130/470 (28%)