Protein Alignment Cyp12a4 and Cyp27b1

DIOPT Version :9

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_446215.1
• Gene: Cyp27b1 / 114700
• RGDID: 69192
• Length: 501
• Species: Rattus norvegicus
• Alignment Length: 498
• Identity: 131/498 - (26%)
• Similarity: 223/498 - (44%)
• Gaps: 77/498 - (15%)

  Fly    67 GKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYH 131
            |....:..:::..|.|  ||.|:  .|..|....:...:|...|.:.|.|...|.|....:...|
  Rat    49 GGLSRLHELQVHGAAR--YGPIW--SGSFGTLRTVYVADPALVEQLLRQESHCPERCSFSSWSEH 109

  Fly   132 REEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRD-- 194
            |..     :|...|::...|:.|...|:::.|:|::|:....|...:..|..:.|:|:...|.
  Rat   110 RRR-----HQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDSVVSDLVRRLRRQRGRG 169

  Fly   195 ---PD-TLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLE 255
               || .|:...:|.    ::.||.:..|.|..:||.|: :....:.......:...|:.:: |.
  Rat   170 SGLPDLVLDVAGEFY----KFGLEGIGAVLLGSRLGCLE-AEVPPDTETFIEAVGSVFVSTL-LT 228

  Fly   256 MK---------PSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEA---KEGVVRPENE 308
            |.         |.||        .||.|..|.:    .|:..:.:|:.:.||   .:|  :||.:
  Rat   229 MAMPSWLHRLIPGPW--------ARLCRDWDQM----FAFAQKHVEQREGEAAVRNQG--KPEED 279

  Fly   309 --------QSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVM- 364
                    ..:..:.:.|...|..|  .::|:|||||.|:|.:..|..|:::||.|:.|..|:.
  Rat   280 LPTGHHLTHFLFREKVSVQSIVGNV--TELLLAGVDTVSNTLSWALYELSRHPEVQSALHSEITG 342

  Fly   365 KVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLN 429
            .|.|...:.....::..:|.|:|.|||..||:|::.||:||..||..:..|.:|..|.|::...
  Rat   343 AVNPGSYAHLQATALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDICVGNYVIPQDTLVSLCHY- 406

  Fly   430 ALTRD-EYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELE 493
            |.:|| ..|.:.:.|.|.|||     .|...|       :||..||||||.|.|:|:|:.|:||:
  Rat   407 ATSRDPAQFREPNSFNPARWL-----GEGPAP-------HPFASLPFGFGKRSCIGRRLAELELQ 459

  Fly   494 LGTARLIRNFNV---EFNYPTENAFRSALINLPNIPLKFKFID 533
            :..|:::.:|.|   ....|.:...|:.|:  |...:..:|:|
  Rat   460 MALAQILTHFEVLPEPGALPVKPMTRTVLV--PERSIHLQFVD 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	p450	72..531	CDD:299894	128/489 (26%)
Cyp27b1	NP_446215.1	CYP27B1	61..496	CDD:410741	128/480 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.880