Protein Alignment Cyp12a4 and cyp24a1

DIOPT Version :10

• Sequence 1: NP_650783.2
• Gene: Cyp12a4 / 42294
• FlyBaseID: FBgn0038681
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_001082927.1
• Gene: cyp24a1 / 100004700
• ZFINID: ZDB-GENE-060825-1
• Length: 505
• Species: Danio rerio
• Alignment Length: 515
• Identity: 138/515 - (26%)
• Similarity: 239/515 - (46%)
• Gaps: 87/515 - (16%)

  Fly    44 AKPFEQIPRLNMWAL---SMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTH- 104
            |...:.||....|.|   .:::...||..:..|.:..|   .:.:|.||.|.  :|:  |.|.|
Zfish    46 AHSLDSIPGPTNWPLFGSLIEVIRNGGLKRQHETLIHF---HKKFGKIFRMK--LGS--FESVHI 103

  Fly   105 -NPQDFEVVFRNEGVWPNR----PGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPV 164
             :|...|.::|.||.:|.|    |.        :.|| |......|::..:|:.|...|:.....
Zfish   104 GSPCLLEALYRKEGSYPERLEIKPW--------KAYR-DMRDEAYGLLILEGRDWQRVRSAFQQK 159

  Fly   165 LMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLK 229
            ||:|..|.....|:::|..:.::||.::..     ..|.....:|:|:.|::..|..||:.|||:
Zfish   160 LMKPTEVMKLDGKINEVAADLIKRIGKVNG-----KMDALYFELNKWSFETICYVIYDKRFGLLQ 219

  Fly   230 NS-NKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVD--EAI 291
            :| :||.        :|  ||.::...|.......:...:|.:.:.        |..:.|  ||.
Zfish   220 DSVSKEG--------MD--FITAVKTMMSTFGTMMVTPVELHKTLN--------TKTWKDHTEAW 266

  Fly   292 ERLDKEAKEGVVRPENEQSVLE------------KLLKVDRKVATVMAMDMLMAGVDTTSSTFTA 344
            :|:...||..:.:...:||..|            .|.|.:...||.   ::.:.||:||:::...
Zfish   267 DRIFSTAKHYIDKNLQKQSNGEADDFLSDIFHNGNLTKKELYAATT---ELQVGGVETTANSMLW 328

  Fly   345 LLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARD 409
            ::..|::||..|.:|.:|:..|:|...:...| .:|::|||:||:|||.|:.|.:...:|.|.:|
Zfish   329 VIFNLSRNPCAQGKLLKEIQDVVPAGQTPRAE-HIKSMPYLKACLKESMRVSPSVPFTSRTLDKD 392

  Fly   410 AVLSGYRVPAGTYVNIVPLNAL---TRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFV 471
            .||..|.:|.||   ::.||:.   ..:|||....:|.|||||            .|..|.|||.
Zfish   393 TVLGDYTLPKGT---VLMLNSQAIGVSEEYFDNGRQFRPERWL------------EEKSSINPFA 442

  Fly   472 FLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFN--YPTENAFRSALINLPNIPLKF 529
            .:|||.|.|||:|:|:.|::::||...::|::.:...  .|.::.....|:....:|:.|
Zfish   443 HVPFGVGKRMCIGRRLAELQIQLGLCWILRDYKIVATDLEPVDSLHSGTLVPSRELPVAF 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a4	NP_650783.2	CYP24A1-like	82..528	CDD:410677	128/471 (27%)
cyp24a1	NP_001082927.1	CYP24A1	84..499	CDD:410738	127/469 (27%)