DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and DIT2

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_010690.1	Gene:	DIT2 / 852011	SGDID:	S000002810	Length:	489	Species:	Saccharomyces cerevisiae

Alignment Length:	522	Identity:	113/522 - (21%)
Similarity:	193/522 - (36%)	Gaps:	109/522 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 EEIPKANILSLFAKSALPGGKYKNLEMMEMIDA-LRQD---YGNIIFLPGMMGRDGLVMTHNPKD 108
            :.||......:|.....|      ::..|:.|. :|:.   ||.:.|   ..|....::....:.
Yeast    31 KNIPTIPFYVVFLPVIFP------IDQTELYDLYIRESMEKYGAVKF---FFGSRWNILVSRSEY 86

  Fly   109 FEVVFRNEGVWPFRPGSDILRYHR-TVYRKDFFDGVQGIIPSQGKSWGDFRSIVN---------P 163
            ...:|::|..:........:.|.. ..|..|      .:|.:.|..|.::|:.|.         |
Yeast    87 LAQIFKDEDTFAKSGNQKKIPYSALAAYTGD------NVISAYGAVWRNYRNAVTNGLQHFDDAP 145

  Fly   164 VLMQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQEVPGNFLETINRWTLESVSVVALDKQLGLL 228
            :.   ||.::           ...|||.........:|...|.  .|..|:::|.|||....|.|
Yeast   146 IF---KNAKI-----------LCTLIKNRLLEGQTSIPMGPLS--QRMALDNISQVALGFDFGAL 194

  Fly   229 RESGKNSEATKLFKYLDE----FFLHSADLEMKPSLWRYFKTPLLKKMLRTMDSVQEVTLKYV-D 288
            ... ||:....|.:...:    |||....|::.|       .|..||..:.:.|.:|:.:|.| |
Yeast   195 THE-KNAFHEHLIRIKKQIFHPFFLTFPFLDVLP-------IPSRKKAFKDVVSFRELLVKRVQD 251

  Fly   289 EAIERLEKE----AKEGVVRPEHEQSVLEKLLKVDKKVATVMAMDMLMAGVDTTSSTFTALLLCL 349
            |.:...:.|    |...::| .|...:      :|.|..|...:.:|:||.:.....|.:.|..|
Yeast   252 ELVNNYKFEQTTFAASDLIR-AHNNEI------IDYKQLTDNIVIILVAGHENPQLLFNSSLYLL 309

  Fly   350 AK-NPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLTRDSVIS 413
            || :.|.|.:||:||..:...|       .:.::|.|.|.:.|..|:||.:.......|..:...
Yeast   310 AKYSNEWQEKLRKEVNGITDPK-------GLADLPLLNAFLFEVVRMYPPLSTIINRCTTKTCKL 367

  Fly   414 GYR--VPAGTIVSMIPINSLYSEEYFPK-----PTEFLPERWLRNASDSAGKCPANDLKT----- 466
            |..  :|.|..|..    :.:...:.||     ..:|.||||            .:|::|
Yeast   368 GAEIVIPKGVYVGY----NNFGTSHDPKTWGTTADDFKPERW------------GSDIETIRKNW 416

  Fly   467 ---KNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHSTKNAFRSALINLP-NIPL 527
               ||......|..|.|.|:|:::...|:.:..|.:::.|....:...:.....|....| |:.|
Yeast   417 RMAKNRCAVTGFHGGRRACLGEKLALTEMRISLAEMLKQFRWSLDPEWEEKLTPAGPLCPLNLKL 481

  Fly   528 KF 529
            ||
Yeast   482 KF 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	107/488 (22%)
DIT2	NP_010690.1	CYP56-like	65..485	CDD:410693	106/482 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24305
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100