DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and cyp27a1.2

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_001334004.3	Gene:	cyp27a1.2 / 795106	ZFINID:	ZDB-GENE-081104-511	Length:	522	Species:	Danio rerio

Alignment Length:	528	Identity:	146/528 - (27%)
Similarity:	253/528 - (47%)	Gaps:	67/528 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NVPTAEIRNDPEWLQAKPFEEIPKANILSLFAKSALPGGKYKN----LEMMEMIDALRQDYGNI- 88
            |...|.:.......:.|...::|:..|.::..:....|  |.|    |::.:     :|.||.:
Zfish    33 NAAAASVSVQDGHRKLKTEADLPEIKIFTMLYQMLFKG--YLNSVHELQLYQ-----KQVYGPLW 90

  Fly    89 -IFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQ-GIIPSQG 151
             |....:.|    :...:.:..|.:.|.:..:|.|....:...||.:      .|:. |....:|
Zfish    91 KINAGNLQG----ISISSVELLEELLRKDEKYPCRGYMTLWTEHRDL------RGISYGPFTEEG 145

  Fly   152 KSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDAS-TQEVPGNFLETINRWTLES 215
            :.|...|:::|..::.||:...|...::.|..:|::.|..:|:.| |.::..|....:.|::||.
Zfish   146 EKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLEG 210

  Fly   216 VSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLW--RYFKTPLLKKMLRTMDS 278
            ::.:..:.::|.| |....:|..|...::.:.|.:|..:.:.|: |  :||  |..:|.:...|.
Zfish   211 IASILFETRIGCL-EKEIPAETQKFINFIAQMFTYSMHVALLPN-WTRKYF--PFWQKYIDGWDG 271

  Fly   279 VQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLL-------KVDKKVATVMAMDMLMAGVD 336
            :.:...|.:|..:|.::|       |.:..|.|..:.|       |:.:|.......::|:||||
Zfish   272 IFKFGTKMIDMKMEAIQK-------RVDTNQDVAGEYLTYLLSNGKISRKDVYGSVSELLLAGVD 329

  Fly   337 TTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEF-TEASMKNVPYLRACIKESQRVYPLVI 400
            :||:|....|..|:|:||.|..|.:||.|||  ||... |...:.::|:|:|.|||:.|:||:|.
Zfish   330 STSNTMLWALYLLSKDPEAQETLYQEVTKVL--KDDRIPTAEEVNSMPFLKAVIKETLRLYPVVP 392

  Fly   401 GNARGLTRDSVISG-YRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDL 464
            .|:|.:....|:.| |..|..|..::........|:.||:|.:|.||||||            |.
Zfish   393 VNSRLIAETEVVIGEYFFPKKTTFTLCHYVISRDEKVFPEPQKFKPERWLR------------DG 445

  Fly   465 KTK-NPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHS---TKNAFRSALINLPNI 525
            :|: |||..:|||||.|.|||:||.|:|:.|..||||:.|.:..:.:   .|..|||.|:  ||.
Zfish   446 RTRPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPDPTVGEVKANFRSVLV--PNK 508

  Fly   526 PLKFKFTD 533
            .:...|.:
Zfish   509 KVNLHFVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	136/468 (29%)
cyp27a1.2	XP_001334004.3	p450	66..505	CDD:278495	137/480 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.780