Protein Alignment Cyp12a5 and cyp27a1.2

DIOPT Version :10

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: XP_073769098.1
• Gene: cyp27a1.2 / 795106
• ZFINID: ZDB-GENE-081104-511
• Length: 580
• Species: Danio rerio
• Alignment Length: 523
• Identity: 145/523 - (27%)
• Similarity: 251/523 - (47%)
• Gaps: 65/523 - (12%)

  Fly    29 NVPTAEIRNDPEWLQAKPFEEIPKANILSLFAKSALPGGKYKN----LEMMEMIDALRQDYGNI- 88
            |...|.:.......:.|...::|:..|.::..:....|  |.|    |::.:     :|.||.:
Zfish   100 NAAAASVSVQDGHRKLKTEADLPEIKIFTMLYQMLFKG--YLNSVHELQLYQ-----KQVYGPLW 157

  Fly    89 -IFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQ-GIIPSQG 151
             |....:.|    :...:.:..|.:.|.:..:|.|....:...||.:      .|:. |....:|
Zfish   158 KINAGNLQG----ISISSVELLEELLRKDEKYPCRGYMTLWTEHRDL------RGISYGPFTEEG 212

  Fly   152 KSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDAS-TQEVPGNFLETINRWTLES 215
            :.|...|:::|..::.||:...|...::.|..:|::.|..:|:.| |.::..|....:.|::||.
Zfish   213 EKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLEG 277

  Fly   216 VSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLW--RYFKTPLLKKMLRTMDS 278
            ::.:..:.::|.| |....:|..|...::.:.|.:|..:.:.|: |  :||  |..:|.:...|.
Zfish   278 IASILFETRIGCL-EKEIPAETQKFINFIAQMFTYSMHVALLPN-WTRKYF--PFWQKYIDGWDG 338

  Fly   279 VQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLL-------KVDKKVATVMAMDMLMAGVD 336
            :.:...|.:|..:|.::|       |.:..|.|..:.|       |:.:|.......::|:||||
Zfish   339 IFKFGTKMIDMKMEAIQK-------RVDTNQDVAGEYLTYLLSNGKISRKDVYGSVSELLLAGVD 396

  Fly   337 TTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEF-TEASMKNVPYLRACIKESQRVYPLVI 400
            :||:|....|..|:|:||.|..|.:||.|||  ||... |...:.::|:|:|.|||:.|:||:|.
Zfish   397 STSNTMLWALYLLSKDPEAQETLYQEVTKVL--KDDRIPTAEEVNSMPFLKAVIKETLRLYPVVP 459

  Fly   401 GNARGLTRDSVISG-YRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDL 464
            .|:|.:....|:.| |..|..|..::........|:.||:|.:|.||||||            |.
Zfish   460 VNSRLIAETEVVIGEYFFPKKTTFTLCHYVISRDEKVFPEPQKFKPERWLR------------DG 512

  Fly   465 KTK-NPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHS---TKNAFRSALINLPNI 525
            :|: |||..:|||||.|.|||:||.|:|:.|..||||:.|.:..:.:   .|..|||..:.:.|.
Zfish   513 RTRPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPDPTVGEVKANFRSLHMYIRNY 577

  Fly   526 PLK 528
            .||
Zfish   578 QLK 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	134/464 (29%)
cyp27a1.2	XP_073769098.1	None