DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and cyp11c1

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_017206857.1	Gene:	cyp11c1 / 791124	ZFINID:	ZDB-GENE-070828-1	Length:	701	Species:	Danio rerio

Alignment Length:	531	Identity:	133/531 - (25%)
Similarity:	218/531 - (41%)	Gaps:	96/531 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 AKPFEEIPKA------NILSLFAKSALPGGKYKNL--EMMEMIDALRQDYGNIIFLPGMMGRDGL 100
            |:.|:|||..      |:|..:.     .|::..:  .|.|....|...|..      .:|....
Zfish   219 ARLFQEIPDTGSNGWMNLLRFWR-----DGRFSRMHKHMEESFRRLGPIYRE------HLGSQSS 272

  Fly   101 VMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVL 165
            |....|.|...:||:||:.|.|........||...|..     :|:....|..|...|.::|..:
Zfish   273 VNIMLPMDTGELFRSEGLHPRRMTLQPWATHRETRRHS-----KGVFLKNGTEWRADRLLLNREV 332

  Fly   166 MQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQEVPGNFLETIN------RWTLESVSVVALDKQ 224
            |...:|..:...:.:|.|:|...::....|...|..|....|::      |:.||:...|...::
Zfish   333 MVSSSVHRFLPLLDEVAQDFCRSLRRRVQADGFEKAGQHTLTLDPSPDLFRFALEASCHVLYGER 397

  Fly   225 LGLLRESGKNSEATKLFKYLDEFFLHSAD---------LEMKPSLWRYFKTPLLKKMLRTMDSVQ 280
            :||. .|..:.|:.:....::.....:..         |.::.|||....|        ..|.:
Zfish   398 IGLF-SSCPSDESERFISAVERMLATTPPLLYLPPRLLLRLRASLWTTHAT--------AWDDI- 452

  Fly   281 EVTLKYVDEAIERLEKEAKEGVVRPEHE-----QSVLEKLLKVDK---KVATVMAMDMLMAGVDT 337
                  ...|.:|:::..:....||...     ..||.||::..:   ::......:::..||||
Zfish   453 ------FSHAEQRIQRSYQRLQARPSAAPDCSFPGVLGKLMEAGQLSLELIRANITELMAGGVDT 511

  Fly   338 TSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEAS------MKNVPYLRACIKESQRVY 396
            |:......|..||:||:.|..:|.:|:       |.:.:||      ::..|.|:..|||:.|:|
Zfish   512 TAVPLQFALFELARNPDVQECVRAQVL-------SSWQQASGDPLKALQGAPLLKGTIKETLRLY 569

  Fly   397 PLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLY----SEEYFPKPTEFLPERWLRNA-SDSA 456
            |:.|...|...||.|:..|.|||||:|.:    .||    |.|.|.:|..|.|.||..:| :.||
Zfish   570 PVGITVQRYPVRDIVLQNYHVPAGTLVQV----CLYPLGRSAEVFSRPECFDPSRWSADADAGSA 630

  Fly   457 GKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHSTKNAFRSALIN 521
            |           .|..|.||||.|.|||:||.|.|::|....::|.|.:..:.:.:.:.:..||.
Zfish   631 G-----------GFRSLAFGFGSRQCVGRRIAENEMQLLLMHILRTFKLTVSSTEELSTKYTLIL 684

  Fly   522 LPNIPLKFKFT 532
            .|..|.:..|:
Zfish   685 QPECPPRITFS 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	122/483 (25%)
cyp11c1	XP_017206857.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820