DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and zgc:136333

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_009303121.1	Gene:	zgc:136333 / 723999	ZFINID:	ZDB-GENE-060616-143	Length:	522	Species:	Danio rerio

Alignment Length:	537	Identity:	147/537 - (27%)
Similarity:	253/537 - (47%)	Gaps:	57/537 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KPIVFSASQQRWQTNVPTAEIRNDPEWLQAKPFEEIPKANILSLFAKSALPGGKYKNLEMMEMID 79
            :|...:...:|...|...|.:.......:.|...::|:..|.::..:....|  |.| .:.|:..
Zfish    19 RPTAAATGFRRAAGNAAAASVSVQDGHRKLKTEADLPEIKIFTMLYQMLFKG--YLN-SIHELQI 80

  Fly    80 ALRQDYGNI--IFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDG 142
            ..:|.||.:  |....:.|    :...:.:..|.:.|.:..:|.|....:...||.:      .|
Zfish    81 YQKQVYGPLSKINSGNLQG----ISISSVELLEELLRKDEKYPCRGYMTLWTEHRDL------RG 135

  Fly   143 V-QGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDAS-TQEVPGNFL 205
            : .|....:|:.|...|:::|..::.||:...|...::.|..:|::.|..:|:.| |.::..|..
Zfish   136 IGYGPFTEEGEKWYKLRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLT 200

  Fly   206 ETINRWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWR-YFKTPLL 269
            ..:.|::||.::.:..:.::|.| |.....|..:....:.:.|.:|..:.:.|:..| ||  |..
Zfish   201 NELYRFSLEGIASILFETRIGCL-EKEIPVETQEFINSIAQMFTYSMHVALLPNWTRNYF--PFW 262

  Fly   270 KKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLL-------KVDKKVATVMA 327
            :|.:...|.:.:...|.:|..:|.::|       |.:..|.|..:.|       |:..|......
Zfish   263 QKYIDGWDGIFKFGTKMIDMKMEAIQK-------RVDTNQEVAGEYLTYLLSSGKMSSKDVYGSV 320

  Fly   328 MDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEF-TEASMKNVPYLRACIKE 391
            .::|:|||||||:|....|..|:|:|..|..|.:||.|||  ||... |...:.::|:|:|.|||
Zfish   321 SELLLAGVDTTSNTMLWALYLLSKDPAAQETLYQEVTKVL--KDDRIPTAEEVNSMPFLKAVIKE 383

  Fly   392 SQRVYPLVIGNARGLTRDSVISG-YRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDS 455
            :.|:||:|..|:|.:....|:.| |..|..|..::......:.|:.||:|.:|.||||||
Zfish   384 TLRLYPVVPVNSRLIAETEVVIGEYFFPKKTTFNLCHYAISHDEKVFPEPQKFKPERWLR----- 443

  Fly   456 AGKCPANDLKTK-NPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHS---TKNAFR 516
                   |.:|: |||..:|||||.|.|||:||.|:|:.|..||||:.|.:..:.:   .|..||
Zfish   444 -------DGRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPDPTVGEVKANFR 501

  Fly   517 SALINLPNIPLKFKFTD 533
            |.|:  ||..:...|.:
Zfish   502 SVLV--PNKKVNLHFVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	135/467 (29%)
zgc:136333	XP_009303121.1	p450	66..505	CDD:278495	136/475 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.780